| 动态增强MRI及1H-MRS诊断乳腺癌:Meta分析 |
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| 引用本文： | 郭定波,陈暇女,欧芳元,黄俊浩,易小琦,胡良波.动态增强MRI及1H-MRS诊断乳腺癌:Meta分析[J].中国医学影像技术,2019,35(3):371-375. |
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| 作者姓名： | 郭定波 陈暇女 欧芳元 黄俊浩 易小琦 胡良波 |
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| 作者单位： | 重庆医科大学附属永川医院放射科, 重庆 402160,重庆医科大学附属永川医院放射科, 重庆 402160,重庆医科大学附属永川医院放射科, 重庆 402160,重庆医科大学附属永川医院放射科, 重庆 402160,重庆医科大学附属永川医院放射科, 重庆 402160,重庆医科大学附属永川医院放射科, 重庆 402160 |
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| 基金项目： | 重庆市卫生计生委医学科研计划重点项目（2017ZDXM020）、重庆市永川区自然科学基金（Ycstc，2015nc5007）。 |
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| 摘 要： | 目的 采用Meta分析方法评价动态增强MRI（DCE-MRI）、1H-MRS及两者联合对乳腺癌的诊断效能。方法 于PubMed、Embase、Cochrane Library、CNKI、万方、维普数据库检索DCE-MRI、1H-MRS及两者联合诊断乳腺癌的相关文献，检索时间自建库至2018年5月。采用Meta-Disc 1.4及STATA 12.0统计分析软件进行Meta分析。结果 共纳入14篇文献。DCE-MRI、1H-MRS及两者联合诊断乳腺癌的敏感度分别为0.9395% CI（0.90，0.95）]、0.8095% CI（0.76，0.83））和0.9595% CI（0.92，0.97）]，特异度分别为0.7795% CI（0.73，0.82）]、0.8195% CI（0.77，0.85）]和0.8395% CI（0.77，0.87）]，诊断比值比分别为43.6995% CI（28.38，67.26）]、24.2495% CI（16.24，36.16））和95.6495% CI（48.90，187.07）），汇总受试者工作特征曲线AUC分别为0.932 9、0.899 9和0.961 9。结论 DCE-MRI及1H-MRS均为乳腺癌的有效诊断方法，两者联合应用诊断效果更佳。
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| 关 键 词： | 乳腺肿瘤 磁共振成像 综合分析 |
| 收稿时间： | 2018/6/13 0:00:00 |
| 修稿时间： | 2018/9/28 0:00:00 |
Dynamic contrast-enhanced MRI and 1H-MRS in diagnosis of breast cancer: Meta-analysis |
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| GUO Dingbo,CHEN Xianv,OU Fangyuan,HUANG Junhao,YI Xiaoqi and HU Liangbo.Dynamic contrast-enhanced MRI and 1H-MRS in diagnosis of breast cancer: Meta-analysis[J].Chinese Journal of Medical Imaging Technology,2019,35(3):371-375. |
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| Authors: | GUO Dingbo CHEN Xianv OU Fangyuan HUANG Junhao YI Xiaoqi and HU Liangbo |
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| Institution: | Department of Radiology, Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, China,Department of Radiology, Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, China,Department of Radiology, Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, China,Department of Radiology, Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, China,Department of Radiology, Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, China and Department of Radiology, Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, China |
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| Abstract: | Objective To observe the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI), 1H-MRS and the combination of them for breast cancer using Meta-analysis. Methods Literatures from PubMed, Embase, Cochrane Library, CNKI, Wanfang and VIP databases were searched from establishment to May 2018, for the diagnostic studies about breast cancer by DCE-MRI, 1H-MRS and the combination of these two methods. Meta-Disc 1.4 and STATA 12.0 software were used for Meta-analysis. Results Totally 14 studies were enrolled. The pooled sensitivity of DCE-MRI, 1H-MRS and the combination of these two methods in diagnosing breast cancer was 0.93 (95%CI0.90, 0.95]), 0.80 (95%CI0.76, 0.83]) and 0.95 (95%CI0.92,0.97]), the pooled specificity was 0.77 (95%CI0.73, 0.82]), 0.81 (95%CI0.77, 0.85]) and 0.83 (95%CI0.77, 0.87]), the pooled diagnostic odds ratio was 43.69 (95%CI28.38,67.26]), 24.24 (95%CI16.24,36.16]) and 95.64 (95%CI48.90, 187.07]), the AUC of summary receiver operating characteristic curve was 0.932 9, 0.899 9 and 0.961 9, respectively. Conclusion DCE-MRI and 1H-MRS are both effective diagnostic technique for breast cancer, and the combination of these two methods can provide more preferable diagnostic accuracy than single use of them. |
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| Keywords: | breast neoplasms magnetic resonance imaging meta-analysis |
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