静脉注射18F-FDG注射液后冲洗注射器对残留剂量及肝脏标准化摄取值的影响

目的 探讨PET/CT检查时静脉注射¹⁸F-FDG注射液后冲洗注射器对放射性药物残留剂量以及肝脏标准化摄取值（SUV）的影响。方法 收集接受PET/CT检查的50例患者，根据注药方式分为对照组（n=25）和实验组（n=25）。采用23G头皮针建立静脉通路，注射¹⁸F-FDG注射液后，对照组直接用5 ml生理盐水冲洗管道；实验组先用1 ml生理盐水冲洗管道，然后用2 ml生理盐水冲洗注射器，最后用剩余2 ml再次冲洗管道。比较2组间¹⁸F-FDG注射后残留剂量以及肝脏SUV平均值（SUV_mean）和SUV最大值（SUV_max）的差异。结果 实验组总残留剂量（0.22±0.08）mCi]、注射器内残留剂量（0.19±0.07）mCi]和静脉通道内残留剂量（0.03±0.02）mCi]均小于对照组（P均<0.01）。实验组与对照组肝脏3个不同层面（第二肝门层面、门静脉左支层面、第一肝门层面）的SUV_mean和SUV_max差异均无统计学意义（P均>0.05）。结论 冲洗注射器能减少¹⁸F-FDG注射液残留量。注射器内少量放射性药物残留尚不足以引起肝脏SUV变化，但进一步规范¹⁸F-FDG注射操作流程仍属必要。

Impact of syringe saline flush after injection of 18F-FDG on residual dose and standardized uptake value of liver

Objective To investigate the impact of saline flush for syringe after ¹⁸F-FDG injection on the residual dose of ¹⁸F-FDG and the standardized uptake value (SUV) of liver during PET/CT examination. Methods A total of 50 patients who underwent PET/CT examination were enrolled and divided into control group (n=25) and experimental group (n=25) according to different injection methods. Device system of the vein passage was established with 23 gauge scalp needle. In control group, the intravenous line was directly flushed with 5 ml physiological saline after ¹⁸F-FDG injection, while in experimental group, firstly the intravenous line was flushed with 1 ml saline, then the syringe was flushed with 2 ml saline, finally the intravenous line was flushed again with the residual 2 ml saline. The residual dose of ¹⁸F-FDG and SUV_mean and SUV_max of liver were compared between the two groups. Results The total residual dose (0.22±0.08]mCi), syringe residual dose (0.19±0.07]mCi) and intravenous channel residual dose (0.03±0.02]mCi) in the experimental group were all lower than those in control group (all P<0.01). There was no significant difference of SUV_mean nor SUV_max between experimental group and control group at 3 different levels of the liver (level of the second liver porta, level of the left portal vein and level of the first liver porta, all P>0.05). Conclusion Flushing the syringe can reduce residual dose of ¹⁸F-FDG injection. A small amount of radiopharmaceuticals retention in the syringe may not affect SUV for liver, but further standardization of the operation process of ¹⁸F-FDG injection is still necessary.