18F-FDG PET/CT评价胃肠间质瘤恶变潜能:Meta分析

目的 采用Meta分析评价¹⁸F-FDG PET/CT评价胃肠间质瘤（GIST）恶变潜能的价值。方法 检索PubMed、EMBASE、Cochrane图书馆、中国知网和中国生物医学数据库中有关¹⁸F-FDG PET/CT评价GIST恶变的中英文文献，检索时间截止2017年12月。由2名研究者进行数据提取和质量评价后，采用Meta-Disc软件进行统计分析。结果 共纳入6项研究、157例患者。Meta分析结果显示，合并敏感度、合并特异度、合并阳性似然比、合并阴性似然比及合并诊断比值比分别为95%CI（0.76，0.92）]、0.7995%CI（0.68，0.87）]、3.3595%CI（1.81，6.20）]、0.2295%CI（0.13，0.37）]，汇总ROC（SROC）曲线下面积为0.9057（P<0.05）。Deek''s漏斗图提示存在发表偏倚的可能性较小。亚组分析和Meta回归分析结果显示诊断试验的准确率基本不受设备型号和SUV_max临界值的影响。结论 ¹⁸F-FDG PET-CT评价胃肠间质瘤恶变潜能具有较高诊断效能。

18F-FDG PET/CT in evaluation on malignant potential of gastrointestinal stromal tumors: Meta-analysis

Objective To explore the value of ¹⁸F-FDG PET/CT in evaluation on the malignant potential of gastrointestinal stromal tumors (GIST) with Meta-analysis. Methods The database of PubMed, EMBASE, Cochrane Library, CNKI and CBM were researched from establishment to December 2017, for the diagnostic studies about assessing the malignant potential of GIST using ¹⁸F-FDG PET/CT. The data were extracted, and the quality of included studies was assessed by 2 reviewers, and then were analyzed with Meta-Disc software. Results Totally 6 studies involving 157 patients were included. Meta-analysis showed that the pooled sensitivity, pooled specificity, pooled positive likelihood ratio, pooled negative likelihood ratio and diagnostic odds ratio was 0.85(95%CI0.76, 0.92]), 0.79 (95%CI0.68, 0.87]), 3.35 (95%CI1.81, 6.20], 0.22 (95%CI0.13, 0.37]) and 18.28 (95%CI6.31, 52.95]), respectively, and the AUC of summary ROC (SROC) was 0.905 7 (P<0.05). Deek''s funnel plot showed that the possibility of publication of bias was small. The subgroup analysis and Meta-regression results indicated that the equipment model and the threshold of SUV_max did not obviously influence the accuracy of ¹⁸F-FDG PET/CT. Conclusion There was high diagnostic efficacy for ¹⁸F-FDG PET/CT in assessing the malignant potential of GIST.