| 18F-FDG PET/CT代谢参数预测原发性宫颈癌预后 |
| |
| 引用本文： | 周星,姚玉唐,李川,王潇雄,江骁,申太鹏,陆皓,陈世容,肖定琼,赵檬,游金辉,程祝忠.18F-FDG PET/CT代谢参数预测原发性宫颈癌预后[J].中国医学影像技术,2020,36(5):726-731. |
| |
| 作者姓名： | 周星 姚玉唐 李川 王潇雄 江骁 申太鹏 陆皓 陈世容 肖定琼 赵檬 游金辉 程祝忠 |
| |
| 作者单位： | 放射肿瘤学四川省重点实验室, 四川省肿瘤医院PET/CT中心, 四川 成都 610041;川北医学院附属医院核医学科, 四川 南充 637000 |
| |
| 基金项目： | 四川省科技计划项目（2018SZ0210、2019YJ0574）。 |
| |
| 摘 要： | 目的 评估根据不同百分比最大标准摄取值（SUVmax）阈值分段代谢参数预测经同步放射化学治疗（CCRT）宫颈癌患者预后的价值。方法 对45例CCRT前宫颈癌患者行18F-FDG PET/CT检查，获得代谢参数最大标准摄取值（SUVmax）、代谢肿瘤体积（MTV）及病灶糖酵解总量（TLG）。利用不同百分比SUVmax阈值（范围10%~85%，以5%递增）分割法分割MTV和TLG，采用ROC曲线分析找出最佳截断值，以 Kaplan-Meier曲线进行生存分析。结果 CCRT后14例肿瘤进展（进展组），31例无进展（非进展组），组间SUVmax、MTV10%、MTV75%~MTV85%、TLG75%~TLG85%差异均无统计学意义（P均>0.05），MTV15%~MTV70%、TLG10%~MTV70%差异有统计学意义（P均<0.05）。以40% SUVmax为阈值预测宫预后作用最强。MTV40%的截断值为21.09时AUC最大（AUC=0.823），敏感度为78.60%，特异度为87.10%；TLG40%的截断值为136.71时AUC最大（AUC=0.788），敏感度为78.60%，特异度为77.40%。结论 根据18F-FDG PET/CT代谢参数MTV40%和TLG40%可预测CCRT后宫颈癌患者预后。
|
| 关 键 词： | 子宫肿瘤 子宫颈 正电子发射断层显像术 体层摄影术 X线计算机 氟脱氧葡萄糖F18 |
| 收稿时间： | 2019/4/13 0:00:00 |
| 修稿时间： | 2019/8/19 0:00:00 |
18F-FDG PET/CT metabolic parameters for prognosis of primary cervical cancer |
| |
| ZHOU Xing,YAO Yutang,LI Chuan,WANG Xiaoxiong,JIANG Xiao,SHEN Taipeng,LU Hao,CHEN Shirong,XIAO Dingqiong,ZHAO Meng,YOU Jinhui,CHENG Zhuzhong.18F-FDG PET/CT metabolic parameters for prognosis of primary cervical cancer[J].Chinese Journal of Medical Imaging Technology,2020,36(5):726-731. |
| |
| Authors: | ZHOU Xing YAO Yutang LI Chuan WANG Xiaoxiong JIANG Xiao SHEN Taipeng LU Hao CHEN Shirong XIAO Dingqiong ZHAO Meng YOU Jinhui CHENG Zhuzhong |
| |
| Institution: | Radiation Oncology Key Laboratory of Sichuan Province, PET/CT Centre, Sichuan Cancer Hospital, Chengdu 610041, China;Department of Nuclear Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China |
| |
| Abstract: | Objective To assess the predictive value of metabolic parameters with different maximum standard intake value (SUVmax) threshold segmentations calculated from 18F-FDG PET/CT before concurrent chemoradiotherapy (CCRT) of cervical cancer. Methods Totally 45 patients underwent 18F-FDG PET/CT before CCRT, and SUVmax, maximum standard intake value (MTV) and metabolic tumor volume (TLG) were recorded. MTV and TLG were automatically segmented using different percentage SUVmax threshold segmentations (10%-85%, increased by 5%). Receiver operating characteristic (ROC) curve analysis was performed in order to obtain the cut-off values of MTV and TLG. Kaplan-Meier method was used for survival analysis. Results SUVmax, MTV10%, MTV75%-MTV85% and TLG75%-TLG85% were not significantly different (all P>0.05), whereas significant differences of MTV15%-MTV70% and TLG10%-TLG70%were found between 2 groups (all P<0.05). 40%SUVmax had the strongest prediction capability for prognosis. Based on ROC curve analysis, the cut-off value of MTV40% was 21.09, with sensitivity of 78.60%, specificity of 87.10% and AUC of 0.823, while the cut-off value of TLG40% was 136.71, with sensitivity of 78.60%, specificity of 77.40% and AUC of 0.788. Conclusion MTV40% and TLG40% calculated from 18F-FDG PET/CT can be taken as prognostic indicators for cervical cancer after CCRT. |
| |
| Keywords: | uterine neoplasms cervix uteri positron-emission tomography tomography X-ray computed fluorodeoxyglucose F 18 |
|
| 点击此处可从《中国医学影像技术》浏览原始摘要信息 |
| 点击此处可从《中国医学影像技术》下载免费的PDF全文 |
|
