超声引导经皮微波消融治疗结直肠癌肝转移瘤不良事件及其影响因素

目的 探讨超声引导经皮微波消融（MWA）治疗结直肠癌肝转移瘤（CRLM）不良事件（AE）及其影响因素。方法 回顾性分析427例接受超声引导经皮MWA治疗的CRLM患者，共治疗614例次、1 334个病灶，统计术后AE发生率及其影响因素。结果 AE总发生率4.89%（30/614），无消融相关死亡。影响AE的危险因素包括穿刺针数（OR=1.301，P=0.005）、高危部位病灶（OR=2.829，P=0.025）、病灶数>5（OR=4.655，P=0.010）、腹腔手术史（OR=7.716，P=0.047）及肝吸虫病（OR=17.683，P=0.005）。结论 超声引导经皮MWA治疗CRLM的AE发生率较低，AE发生与病灶数目、高危部位、穿刺针数、腹腔手术史及肝吸虫病有关。

Incidence and impact factors of adverse events in patients with colorectal liver metastases treated with ultrasound-guided percutaneous microwave ablation

Objective To investigate the incidence and impact factors of adverse events (AE) in ultrasound-guided percutaneous microwave ablation (MWA) for treatment of colorectal liver metastases (CRLM). Methods Clinical data of 427 CRLM patients who underwent ultrasound-guided percutaneous MWA were retrospectively analyzed. Totally 614 MWA sessions were performed and 1 334 lesions were ablated. The incidence and impact factors of AE were analyzed. Results The overall incidence of AE was 4.89% (30/614), and no ablation-related death occurred. The risk factors affecting AE included number of insertions (OR=1.301, P=0.005), lesions at high-risk areas (OR=2.829, P=0.025), more than 5 lesions (OR=4.655, P=0.010), history of abdominal surgery (OR=7.716, P=0.047) and clonorchiasis (OR=17.683, P=0.005). Conclusion The incidence of AE in ultrasound-guided percutaneous MWA for CRLM is low. The number of lesions and insertions, lesions at high-risk areas, history of abdominal surgery, and clonorchiasis are associated with the incidence of AE.