中药单体治疗青光眼的研究进展

青光眼(glaucoma)是一组进行性视神经损害，导致视力损伤的疾病，是人类首要不可逆致盲性眼病，病理性眼压升高是其危险因素。临床上常用降眼压类与保护视神经类药物治疗，以对症治疗为主，疗效不理想。中药单体兼有中药与化药双重优势，我国传统中药与中药单体在青光眼治疗，特别是视神经保护方面具有独特优势，可供研发的空间很大。本文综述了代表性组方与单味中药，尤其是代表性中药单体在青光眼治疗中的应用与机制，以期为青光眼临床治疗与新药研发提供参考。

Advances of anti-glaucoma Chinese herb monomers

Glaucoma is an eye disease characterized by progressiveretinal nerve damage and impaired vision, which is the top one irreversible blinding eye disease. The pathologic intraocular pressure elevation is its key risk. At present, the clinical medicine with intraocular pressure reducing and retinal nerve protection effects focused on symptomatic therapy with unsatisfied effects. Chinese herb monomers have advantages of both Chinese herbs and chemical drugs. Chinese herbs and Chinese herb monomers have favorable effects on glaucoma therapy, especially on retinal nerve protection, which provides a vast room for new drug development. The paper summarized applications and mechanism of representative anti-glaucoma Chinese herbal formulas, Chinese herbs and especially Chinese herb monomers, which would provide references for clinical therapy and new drug development for glaucoma.