航天飞行后立位耐力不良的中医病因病机及防护措施研究进展

重力环境和力学载荷是生命体所面对的重要环境因素，当这些因素改变时，会造成细胞内质网内稳态失衡，引起内质网应激及未折叠蛋白反应。本文通过调研近年来微重力及其他力学载荷下细胞内质网应激及未折叠蛋白反应的相关文献，从内质网形态、未折叠蛋白反应、内质网功能蛋白及微重力下的自噬与凋亡等方面，总结了微重力下内质网应激及未折叠蛋白反应的研究进展，以期揭示微重力下内质网应激的发生机理，从干预内质网应激及未折叠蛋白反应的角度，寻找用于对抗微重力下细胞功能异常改变的新方法。

Research Progress of TCM Etiology, Pathogenesis and Protective Measures for Post Spaceflight Orthostatic Intolerance

Gravity environment and mechanical loading are important environmental factors faced by life. The changing of those factors will cause homeostasis imbalance in endoplasmic reticulum, lead to endoplasmic reticulum stress (ERS) and unfolded protein response (UPR). Based on the relevant literature on endoplasmic reticulum stress and unfolded protein response induced by microgravity or other mechanical loading in recent years, from the aspects of endoplasmic reticulum morphology, unfolded protein reaction, endoplasmic reticulum functional protein and autophagy and apoptosis under microgravity, the research progress of endoplasmic reticulum stress and unfolded protein response induced by microgravity was summarized. The prospection of this paper is to reveal the mechanism of endoplasmic reticulum stress under microgravity, on the other hand, to explore new methods resisting abnormal changes of cell function under microgravity from the perspective of intervening endoplasmic stress and unfolded protein response.