特发性癫痫患儿静息态自发神经活动低频振荡振幅改变

目的 探讨特发性癫痫（IE）患儿的静息态自发神经活动低频振荡振幅（ALFF）改变。方法 收集17例IE患儿（IE组）和14名性别、年龄等相匹配的健康儿童（对照组），采集其全脑结构和静息态fMRI数据，以DPARSF软件计算大脑静息态ALFF。采用多变量回归模型，比较2组间ALFF差异，分析ALFF与病程的相关性。结果 与对照组比较，IE组ALFF增高脑区包括右侧脑干、左侧小脑和左侧海马旁回；ALFF减低脑区包括双侧前扣带回、双侧眶回、左侧三角部额下回、左侧额中回、双侧顶下小叶、双侧角回（P均<0.05，3dClustSim校正）。多变量回归分析发现，右侧脑干ALFF值与病程呈正相关（最强显著相关体素点r=0.82，P<0.05，3dClustSim校正）。结论 IE患儿静息态自发神经活动存在明显改变，且右侧脑干ALFF值与病程相关，为理解儿童IE的潜在神经机制提供了客观依据。

Amplitude of low-frequency fluctuation in resting-state spontaneous brain activity in children with idiopathic epilepsy

Objective To explore the features of the amplitude of low-frequency fluctuation (ALFF) in resting-state brain activity in children with idiopathic epilepsy (IE). Methods Totally 17 children with IE (IE group) and 14 matched controls (control group) were recruited. The structural and resting-state fMRI data were collected, and ALFF was computed with DPARSF software. The difference of ALFF between 2 groups was explored with the multivariate regression model, and the age and gender were considered as covariates. The correlation between ALFF and duration of disease was evaluated. Results Compared with control group, increased ALFF brain regions were observed in right brainstem, left cerebellum and parahippocampus in IE group, and reduced ALFF brain regions were observed in bilateral anterior cingulate gyrus, bilateral orbital frontal cortex, left superior frontal gyrus, left middle frontal gyrus, bilateral parietal lobule and bilateral angular gyrus (all P<0.05, 3dClustSim corrected). The multivariate regression analysis showed that ALFF in the right brainstem was positively correlated with the duration of IE (r=0.82, P<0.05, 3dClustSim corrected). Conclusion The spontaneous brain activity in children with IE alters and associates with duration of disease. These findings may be evidences for elucidating potential neural mechanism of IE in childhood.