| 基于体素形态学和表面形态计量学MRI观察肌萎缩侧索硬化患者大脑结构改变 |
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| 引用本文： | 王倩楠,张静娜,张晔,李鹏岳,桑林琼,王莉,吴春玲,胡俊,邱明国.基于体素形态学和表面形态计量学MRI观察肌萎缩侧索硬化患者大脑结构改变[J].中国医学影像技术,2018,34(12):1772-1776. |
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| 作者姓名： | 王倩楠 张静娜 张晔 李鹏岳 桑林琼 王莉 吴春玲 胡俊 邱明国 |
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| 作者单位： | 陆军军医大学生物医学工程与影像医学系医学图像学教研室, 重庆 400038,陆军军医大学生物医学工程与影像医学系医学图像学教研室, 重庆 400038,陆军军医大学生物医学工程与影像医学系医学图像学教研室, 重庆 400038,陆军军医大学生物医学工程与影像医学系医学图像学教研室, 重庆 400038,陆军军医大学生物医学工程与影像医学系医学图像学教研室, 重庆 400038,陆军军医大学生物医学工程与影像医学系医学图像学教研室, 重庆 400038,陆军军医大学生物医学工程与影像医学系医学图像学教研室, 重庆 400038,陆军军医大学附属第一医院神经内科, 重庆 400038,陆军军医大学生物医学工程与影像医学系医学图像学教研室, 重庆 400038 |
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| 基金项目： | 国家自然科学基金青年科学基金项目（81601970）、陆军军医大学第一附属医院转化医学合作课题（SWH2014ZH03）。 |
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| 摘 要： | 目的 探讨肌萎缩侧索硬化（ALS）患者大脑形态结构的改变，以期寻找有效的早期诊断影像学标记。方法 采集27例临床确诊ALS患者（ALS组）和27名健康志愿者（对照组）的3D-T1W脑结构像，分别以基于体素形态学（VBM）和基于表面形态计量学（SBM）方法对全脑结构进行分析。将2种算法得到的ALS组有显著差异脑区的灰质体积与临床修订版ALS功能评分量表（ALSFRS-R）评分分别进行相关分析。结果 VBM分析结果显示，与对照组比较，ALS组双侧中央前回、左侧背侧丘脑、右侧辅助运动区、左侧中央沟盖、双侧中央后回等运动相关脑区灰质体积显著减小，双侧额叶、颞叶、枕叶及海马旁回等运动区以外的脑区灰质体积亦缩小。SBM分析结果显示，与对照组比较，ALS组右侧BA4a、BA4p区灰质体积和皮层厚度降低。ALS组右侧BA4a区灰质体积与ALSFRS-R评分呈正相关（r=0.418，P=0.038）。结论 ALS患者大脑运动区和运动区域以外脑结构均有所改变，BA4a区的灰质体积及皮层厚度有望作为生物学标记物，用于监测疾病病程进展。
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| 关 键 词： | 肌萎缩侧索硬化 基于体素形态学 基于表面形态计量学 磁共振成像 |
| 收稿时间： | 2018/4/24 0:00:00 |
| 修稿时间： | 2018/9/14 0:00:00 |
Voxel-based morphological analysis and surface-based morphometry MRI observation on brain structural changes in patients with amyotrophic lateral sclerosis |
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| WANG Qiannan,ZHANG Jingn,ZHANG Ye,LI Pengyue,SANG Linqiong,WANG Li,WU Chunling,HU Jun and QIU Mingguo.Voxel-based morphological analysis and surface-based morphometry MRI observation on brain structural changes in patients with amyotrophic lateral sclerosis[J].Chinese Journal of Medical Imaging Technology,2018,34(12):1772-1776. |
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| Authors: | WANG Qiannan ZHANG Jingn ZHANG Ye LI Pengyue SANG Linqiong WANG Li WU Chunling HU Jun and QIU Mingguo |
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| Institution: | Teaching and Research Section of Medical Imaging, College of Biomedical Engineering & Imaging Medicine, Army Medical University, Chongqing 400038, China,Teaching and Research Section of Medical Imaging, College of Biomedical Engineering & Imaging Medicine, Army Medical University, Chongqing 400038, China,Teaching and Research Section of Medical Imaging, College of Biomedical Engineering & Imaging Medicine, Army Medical University, Chongqing 400038, China,Teaching and Research Section of Medical Imaging, College of Biomedical Engineering & Imaging Medicine, Army Medical University, Chongqing 400038, China,Teaching and Research Section of Medical Imaging, College of Biomedical Engineering & Imaging Medicine, Army Medical University, Chongqing 400038, China,Teaching and Research Section of Medical Imaging, College of Biomedical Engineering & Imaging Medicine, Army Medical University, Chongqing 400038, China,Teaching and Research Section of Medical Imaging, College of Biomedical Engineering & Imaging Medicine, Army Medical University, Chongqing 400038, China,Department of Neurology, the First Affiliated Hospital of Army Medical University, Chongqing 400038, China and Teaching and Research Section of Medical Imaging, College of Biomedical Engineering & Imaging Medicine, Army Medical University, Chongqing 400038, China |
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| Abstract: | Objective To investigate brain morphological changes in patients with amyotrophic lateral sclerosis (ALS), and to find effective diagnostic imaging markers of ALS. Methods 3D-T1W structural images of 27 clinically diagnosed ALS patients (ALS group) and 27 healthy volunteers (control group) were acquired and analyzed using voxel-based morphological analysis (VBM) and surface-based morphometry (SBM). The brain regions with different grey matter volume were obtained, and the correlation with the revised ALS functional rating scale (ALSFRS-R) scores was evaluated. Results VBM analysis results showed that the gray matter volume of brain regions associated with motor areas decreased in ALS group compared with control group, including bilateral precentral gyrus, left dorsal thalamus, right supplementary motor area, left Rolandic and bilateral postcentral gyrus and so on. Meanwhile, gray matter volume of the extra-motor brain regions including both frontal, temporal, occipital and parahippocampal gyrus also decreased. SBM analysis results showed that the cortical thickness and volume in right BA4a and BA4p regions of ALS group were significantly lower than those in control group. The gray matter volume in the right BA4a area of ALS group significantly positively correlated with ALSFRS-R score (r=0.418, P=0.038). Conclusion The brain structure of cerebral motor area and extra-motor area of ALS patients has changed. The cortical thickness and volume of BA4a area are expected to serve as biomarkers for monitoring ALS progression. |
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| Keywords: | Amyotrophic lateral sclerosis Voxel-based morphometry Surface-based morphometry Magnetic resonance imaging |
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