| 动脉自旋标记成像用于轻度认知障碍研究进展 |
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| 引用本文： | 邱明娟,席芊.动脉自旋标记成像用于轻度认知障碍研究进展[J].中国医学影像技术,2020,36(7):1093-1096. |
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| 作者姓名： | 邱明娟 席芊 |
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| 作者单位： | 同济大学附属东方医院医学影像科, 上海 200120 |
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| 基金项目： | 国家自然科学基金（81301200）、上海市卫生和计划生育委员会科研项目（201740207）、上海市浦东新区卫生系统学科带头人培养计划项目（PWRd2016-07）。 |
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| 摘 要： | 轻度认知障碍（MCI）是阿尔茨海默病（AD）的前驱期，对其发病机制尚不明确。脑血流量是衡量脑功能的重要指标，各种原因致局部脑血流量（rCBF）减低而损伤大脑。动脉自旋标记（ASL）MRI是通过磁化标记动脉血中氢质子作为内源性示踪剂测量rCBF的成像技术。本研究针对ASL成像在早期诊断MCI、监测疾病进展及评估疗效中的研究进展进行综述。
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| 关 键 词： | 轻度认知障碍 磁共振成像 局部脑血流量 |
| 收稿时间： | 2019/7/13 0:00:00 |
| 修稿时间： | 2020/2/25 0:00:00 |
Research progresses of arterial spin labeling imaging in mild cognitive impairment |
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| QIU Mingjuan,XI Qian.Research progresses of arterial spin labeling imaging in mild cognitive impairment[J].Chinese Journal of Medical Imaging Technology,2020,36(7):1093-1096. |
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| Authors: | QIU Mingjuan XI Qian |
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| Institution: | Department of Medical Imaging, East Hospital Affiliated to Tongji University, Shanghai 200120, China |
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| Abstract: | Mild cognitive impairment (MCI) is a prodromal stage of Alzheimer''s disease (AD), the pathogenesis of AD is still unclear. Cerebral blood flow is an important indicator of brain function. Various causes lead to decreased regional cerebral blood flow (rCBF) and damage brain. Arterial spin labeling (ASL) MRI is an imaging technology that measure rCBF by magnetizing hydrogen protons in labeled arterial blood as endogenous tracers. The progresses of ASL imaging in early diagnosis and monitoring progression as well as evaluation on therapeutic effects of MCI were reviewed in this article. |
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| Keywords: | mild cognitive impairment magnetic resonance imaging regional cerebral blood flow |
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