血清miR-93在子宫内膜癌中的表达及临床意义

目的探讨血清miR-93在子宫内膜癌(endometrial carcinoma,EC)中的表达及其临床意义。方法选取2016年10月至2018年12月在安徽医科大学附属六安医院接受治疗的EC患者133例作为EC组,同期接受治疗的子宫良性疾病患者87例作为良性对照组,同期在我院体检的健康志愿者82例作为健康对照组。比较3组研究对象血清miR-93、糖类抗原125(carbohydrate antigen 125,CA125)、人附睾分泌蛋白E4(human epididymal secretory protein E4,HE 4)的水平,分析其血清水平与EC患者临床病理特征之间的关系,以及对EC的早期诊断及淋巴结转移预测的价值。结果EC组的血清miR-93、CA125、HE4水平高于良性对照组和健康对照组(P<0.05)。EC患者血清miR-93水平与FIGO分期、分化程度、肌层浸润深度、淋巴结转移有关(P<0.05);EC患者血清CA125水平与FIGO分期、肌层浸润深度、淋巴结转移有关(P<0.05);EC患者血清HE 4水平与年龄、FIGO分期、肌层浸润深度、淋巴结转移有关(P<0.05);血清miR-93对EC有较高的早期诊断价值及淋巴结转移预测价值,且在与CA125、HE4联合检测后,对EC的早期诊断价值及淋巴结转移预测价值将会得到进一步提升。结论miR-93在EC患者血清中呈高表达,且与FIGO分期、分化程度、肌层浸润深度、淋巴结转移有关,对EC有较高的早期诊断价值及淋巴结转移预测价值,联合CA125、HE4可进一步提高其临床应用价值。

Expression of serum miR-93 in endometrial carcinoma and its clinical significance

Objective To investigate the expression and clinical significance of serum miR-93 in endometrial cancer(EC).Methods From October 2016 to December 2018,133 patients with EC who were treated at Lu’an Hospital Affiliated to Anhui Medical University were selected as the EC group,87 patients with benign uterine diseases who were treated in the same period were used as benign control group,and 82 healthy volunteers who were examined in our hospital during the same period were used as healthy control group.The levels of serum miR-93,carbohydrate antigen 125(CA125)and human epididymal secretory protein E 4(HE4)were compared between the three groups.The serum levels were analyzed between the clinician and the clinicopathological features of EC patients.The relationship,as well as its value for early diagnosis of EC and prediction of lymph node metastasis.Results Serum levels of miR-93,CA125 and HE4 in the EC group were higher than those in the benign control group and the healthy control group(P<0.05).Serum miR-93 levels in EC patients were associated with FIGO stage,degree of differentiation,depth of myometrial invasion,and lymph node metastasis(P<0.05).Serum CA125 levels in EC patients were associated with FIGO stage,depth of myometrial invasion,and lymph node metastasis(P<0.05).Serum HE4 levels in EC patients were associated with age,FIGO stage,depth of myometrial invasion,and lymph node metastasis(P<0.05).Serum miR-93 had a higher early diagnostic value and predictive value of lymph node metastasis,and was associated with CA125.After combined detection of HE4,the value of early diagnosis of EC and the predictive value of lymph node metastasis will be further improved.Conclusion miR-93 is highly expressed in the serum of EC patients,and is associated with FIGO stage,differentiation degree,depth of myometrial invasion and lymph node metastasis.It has high early diagnostic value and predictive value of lymph node metastasis.It can be combined with CA125 and HE4 to further improve its clinical application value.