| 肾上腺素注射液中亚硫酸氢钠的含量测定 |
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| 引用本文： | 汪志强,文瑾,方夏琴,王登才,张宇佳,郑稳生. 肾上腺素注射液中亚硫酸氢钠的含量测定[J]. 药学研究, 2018, 37(12): 699-701,738 |
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| 作者姓名： | 汪志强 文瑾 方夏琴 王登才 张宇佳 郑稳生 |
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| 作者单位： | 1.中国医学科学院药物研究所，药物传输技术及新型制剂北京市重点实验室，北京 100050；2.安徽中医药大学，安徽 合肥 230012,3.中国药学会，北京 100022,1.中国医学科学院药物研究所，药物传输技术及新型制剂北京市重点实验室，北京 100050,1.中国医学科学院药物研究所，药物传输技术及新型制剂北京市重点实验室，北京 100050；2.安徽中医药大学，安徽 合肥 230012,1.中国医学科学院药物研究所，药物传输技术及新型制剂北京市重点实验室，北京 100050,1.中国医学科学院药物研究所，药物传输技术及新型制剂北京市重点实验室，北京 100050 |
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| 基金项目： | 中国医学科学院医学与健康科技创新工程项目（No.2017-12M-1-011） |
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| 摘 要： | 目的 建立肾上腺素注射液中抗氧化剂亚硫酸氢钠的含量测定方法。方法 基于在SO2存在下可以使得酸性品红溶液褪色的原理，采用比色法在548 nm波长处测定样品吸光度，根据吸光度值计算抗氧化剂的含量。结果 在亚硫酸氢钠浓度为4～24 μg·mL-1，吸光度值的倒数与其浓度呈良好的线性关系Y=0.007 8X+1.628 6（R2=0.999 5），平均回收率为102.50%（RSD=2.22%，n=9）。结论 该方法准确，简便易行，可用于对肾上腺素注射液中亚硫酸氢钠含量的测定。
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| 关 键 词： | 肾上腺素注射液；亚硫酸氢钠；含量；比色法 |
Determination of sodium bisulfite in Epinephrine Injection |
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| WANG Zhiqiang,WEN Jin,FANG Xiaqin,WANG Dengcai,ZHANG Yujia and ZHENG Wensheng. Determination of sodium bisulfite in Epinephrine Injection[J]. Journal of Pharmaceutical Research, 2018, 37(12): 699-701,738 |
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| Authors: | WANG Zhiqiang WEN Jin FANG Xiaqin WANG Dengcai ZHANG Yujia ZHENG Wensheng |
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| Affiliation: | 1.Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing City Key laboratory of Drug Delivery Technology and Novel Formulation,Beijing 100050,China;2.Chinese Pharmaceutical Association,Beijing 100022,China;3.Anhui University of Chinese Medicine,Hefei 230012,China,1.Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing City Key laboratory of Drug Delivery Technology and Novel Formulation,Beijing 100050,China;2.Chinese Pharmaceutical Association,Beijing 100022,China;3.Anhui University of Chinese Medicine,Hefei 230012,China,1.Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing City Key laboratory of Drug Delivery Technology and Novel Formulation,Beijing 100050,China;2.Chinese Pharmaceutical Association,Beijing 100022,China;3.Anhui University of Chinese Medicine,Hefei 230012,China,1.Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing City Key laboratory of Drug Delivery Technology and Novel Formulation,Beijing 100050,China;2.Chinese Pharmaceutical Association,Beijing 100022,China;3.Anhui University of Chinese Medicine,Hefei 230012,China,1.Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing City Key laboratory of Drug Delivery Technology and Novel Formulation,Beijing 100050,China;2.Chinese Pharmaceutical Association,Beijing 100022,China;3.Anhui University of Chinese Medicine,Hefei 230012,China and 1.Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing City Key laboratory of Drug Delivery Technology and Novel Formulation,Beijing 100050,China;2.Chinese Pharmaceutical Association,Beijing 100022,China;3.Anhui University of Chinese Medicine,Hefei 230012,China |
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| Abstract: | |
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| Keywords: | Epinephrine Injection Sodium bisulfite Assay Colorinetry |
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