八段锦对骨质疏松症患者干预效果的Meta分析

目的针对八段锦对骨质疏松症患者的干预效果进行系统评价。方法计算机检索PubMed、The Cochrane Library、EMbase、CBM、CNKI、维普、万方等数据库,纳入符合标准的RCT,检索时间从建库至2019年1月。由两位研究者按照纳入和排除标准独立进行文献筛选、提取资料及质量评价,应用RevM an 5. 3、Stata 12. 0统计软件进行Meta分析。结果合计纳入15项RCT,包括1 154名研究对象。Meta分析结果显示,与对照组相比,八段锦组提高了骨质疏松患者的总有效率、血清骨钙素水平(BGP)、血清碱性磷酸酶(ALP),降低了患者的疼痛评分(VAS),差异有统计学意义(P0. 05);在血清Ca~(2+)水平方面,两组患者无明显差异。在提高骨密度(bone mineral density,BMD)方面,八段锦组优于对照组,差异有统计学意义(P0. 05);但亚组分析显示腰椎BMD差异有统计学意义,股骨颈BMD差异无统计学意义。结论八段锦运动治疗骨质疏松症具有良好疗效,但纳入研究数量、质量有限,尚需要高质量、大样本的随机对照试验加以证实。

Meta-analysis of the effects of Baduanjin on patients with osteoporosis

Objective To estimate the effects of Baduanjin on patients with osteoporosis systematically. Methods PubMed, The Cochrane Library, EMbase, CBM, CNKI, VIP, Wanfang Database and other databases were searched by computer for RCTs met the inclusion criteria. The retrieval time was from the establishment of the database to January 2019. Two reviewers independently screened the literature, extracted data and evaluated the quality according to the inclusion and exclusion criteria. Meta-analysis was performed by RevMan 5.3, Stata12.0 statistical software. Results In total 15 RCTs were included, involving 1154 patients. Meta-analysis revealed that compared with the control group, Baduanjin group had increased total effective rate in osteoporosis patients, increased serum osteocalcin level (BGP) and serum alkaline phosphatase (ALP), and decreased pain score of patients (VAS), with statistical significance. The two groups had no significant difference in serum Ca2+ level. In terms of improving bone mineral density (BMD), Baduanjin group was better than the control group, which was statistically significant. However, subgroup analysis suggested that the effect on lumbar spine bone density was statistically significant, but femoral neck bone density showed no significant difference. Conclusion Baduanjin exercise has a good efficacy in the treatment of osteoporosis, which is limited by the quantity and quality of the studies, and needs to be confirmed by high-quality, large-sample randomized controlled trials.