59例药源性胰腺炎文献分析

目的 探讨药源性胰腺炎发生的特点，为临床安全用药提供参考。方法 检索中国期刊全文数据库1981~2018年报道的药源性胰腺炎个案病例文献，并对其进行汇总分析。结果 共纳入56篇文献，59例病例。发生药源性胰腺炎较多的药物为抗肿瘤药物(28.81%)、抗感染药物(23.73%)及激素相关性药物(15.25%)；10岁以下患者构成比最高(22.03%)。59例患者中，31例发生在给药1周以内(52.54%)，54例患者治愈(91.53%)，4例患者死亡(6.78%)，情况不明患者1例(1.69%)。结论 左旋门冬酰胺酶、替加环素、利福平及泼尼松等易诱发药源性胰腺炎，临床应用以上药物时需密切关注患者症状。

Literature analysis of 59 cases of drug-induced pancreatitis

Objective To investigate characteristics of drug-induced pancreatitis, supplying evidences for rational drug use in clinical practice.Methods Related literatures of drug-induced pancreatitis published on CNKI database from 1987 to 2018 were collected and analyzed.Results A total of 56 articles were included, involving 59 cases. Anticancer drugs, anti-infective drugs and hormone drugs were associated with high occurrence rate (28.81%,23.73% and 15.25%,respectively). Patients aged less than 10 years old appear to have highest occurrence rate (22%). Of 59 cases, 31cases (52.54%) occurred within one week, 54 cases (91.53%) were cured, 4 cases (6.78%) were died and 1 cases (1.69%) was unclear.Conclusion L-asparaginase,tegacycline, rifampicin and prednisone can easily induce drug-induced pancreatitis so patients'' symptoms should be paid close attention to in the clinical application of the above drugs.