实时CEUS评估甲状腺乳头状癌侵袭性及其与病理微血管密度的关系

目的 探讨CEUS评估甲状腺乳头状癌（PTC）侵袭性的价值及其与病理微血管密度（MVD）的关系。方法 分析52例经手术病理证实的PTC的CEUS特征，并对术后病理切片进行MVD计数，分析MVD计数与CEUS特征的关系。结果 PTC结节周边区计数高于中心区（t=0.024，P=0.041），同时有颈部淋巴结转移PTC患者结节周边区MVD计数高于无颈部淋巴结转移的PTC患者（P=0.039）。PTC结节周边区时间-强度曲线AUC与结节周边区、结节总体MVD计数呈正相关（r=0.45、0.41，P均<0.05）。结论 PTC的CEUS表现差异与病理MVD计数相关；CEUS定量分析对评估PTC侵袭性具有重要价值。

CEUS in evaluating invasiveness of papillary thyroid carcinoma and relationship with pathological microvessel density

Objective To explore the value of CEUS in evaluating invasiveness of papillary thyroid carcinoma (PTC) and the relationship with pathological microvessel density (MVD). Methods CEUS characteristics of 52 patients with PTC confirmed by surgical pathology were analyzed. MVD was counted in the postoperative pathological sections, and the relationship between MVD and CEUS features was analyzed. Results The peripheral MVD of PTC was higher than that in the central PTC (t=0.024, P=0.041), and peripheral MVD in patients with cervical lymph node metastasis were higher than that of non-metastatic patients (P=0.039). The time-intensity curve AUC of the peripheral area of the nodules was positively correlated with MVD count of the peripheral areas of the nodules and the total nodules (r=0.45, 0.41, both P<0.05). Conclusion CEUS characteristics of papillary thyroid carcinoma are correlated with MVD. CEUS quantitative analysis technique has certain value of evaluating the invasiveness PTC.