自噬对放射敏感性的影响

自噬广泛存在于真核生物中,利用溶酶体降解受损细胞器或蛋白质,维持细胞内环境的稳定,并提供能量;且通过自噬相关基因和信号通路参与肿瘤细胞的生长、增殖及凋亡。放疗是肿瘤治疗的主要方法之一,但肿瘤细胞常存在放射抵抗,降低疗效。有研究表明自噬与肿瘤细胞的放射敏感性相关,但结论不一。文章就自噬对肿瘤放射敏感性的不同影响作一综述。

Effects of autophagy on radiosensitivity

Autophagy extensively exists in eukaryotes,which utilizes lysosomes to degrade the damaged organelles or proteins,maintain the stability of the intracellular environment and provide energy. It can also participate in the growth,proliferation and apoptosis of tumor cells through autophagy-related genes and signaling pathways. Radiotherapy is one of the main treatments for cancer,whereas tumor cells often have radiation resistance, which reduces the clinical efficacy. Previous studies have demonstrated that autophagy is associated with the radiosensitivity of tumor cells, but the conclusions are different. In this article, different effects of autophagy upon the radiosensitity of tumor cells were reviewed.