18F-FDG PET/CT参数联合临床特征预测手术治疗早期宫颈癌患者预后

目的探讨18 F-FDG PET/CT参数联合临床特征对预测早期宫颈癌患者手术治疗后预后的价值。方法回顾性分析70例术前接受18 F-FDG PET/CT检查的早期宫颈癌患者,比较术后复发组与无复发组间代谢参数的差异,评价18 F-FDG PET/CT参数结合临床特征对预后的预测价值。结果术后平均随访(53.86±15.74)个月,期间11例(11/70,15.71%)肿瘤复发。相关18 F-FDG PET/CT参数中,峰值标准摄取值(SUV peak)可预测肿瘤复发(AUC=0.672,P=0.03)。多因素比例风险模型(Cox)显示,淋巴结转移状态及SUV peak是最主要的预测因素。结论SUV peak和淋巴结转移状态是评价手术治疗后早期宫颈癌患者预后的主要指标。

18F-FDG PET/CT parameters combined with clinical features in predicting prognosis of patients with early cervical cancer

Objective To explore the prognostic value of ¹⁸F-FDG PET/CT parameters combined with clinical features in predicting prognosis of early cervical cancer patients after surgical operation. Methods A total of 70 cervical cancer patients who underwent ¹⁸F-FDG PET/CT before operation were collected and retrospectively analyzed. Differences of metabolic parameters were compared between relapsed patients (relapse group) and non-recurrent ones (non-recurrent group). The predictive value of ¹⁸F-FDG PET/CT parameters combined with clinical features for prognosis were analyzed. Results The mean follow-up time was (53.86±15.74) months, and recurrence of cervical cancer occurred in 11 patients (11/70, 15.71%). The peak standard uptake value (SUV_peak) was the only ¹⁸F-FDG PET/CT parameter predicting recurrence (AUC=0.672, P=0.03). Multivariate proportional hazards model (Cox) showed that lymph node metastatic status and SUV_peak were the most important predictors. Conclusion SUV_peak and lymph node metastatic status are main indicators for evaluating prognosis of patients with early cervical cancer after surgical operation.