| 肥胖儿童高血压发病因素和机理的研究 |
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| 引用本文： | 朱树森,符云峰,王素敏,卢振敏,孙爱励.肥胖儿童高血压发病因素和机理的研究[J].天津医药,2001,29(5):259-261. |
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| 作者姓名： | 朱树森 符云峰 王素敏 卢振敏 孙爱励 |
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| 作者单位： | 1. 石家庄,河北省医学科学院生化研究室
2. 石家庄,河北省医学科学院测试中心 |
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| 摘 要： | 目的探讨儿童肥胖引起高血压的机制。方法测定104例12～16岁中学儿童的血脂、胰岛素水平，
Na
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| 关 键 词： | 肥胖症 儿童 高血压 胰岛素 Na |
| 修稿时间： | 2000年4月7日 |
Pathogenic Factors and
Mechanism of Hypertension in Obese Children |
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| ZHU Shusen,FU Yunfeng,WANG Sumin,et al.Pathogenic Factors and
Mechanism of Hypertension in Obese Children[J].Tianjin Medical Journal,2001,29(5):259-261. |
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| Authors: | ZHU Shusen FU Yunfeng WANG Sumin |
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| Institution: | ZHU Shusen,FU Yunfeng,WANG Sumin,et al Department of Biochemistry,Hebei Academy of Medical Science,Shijiazhuang 050021 |
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| Abstract: | Objective:To explore the mechanism of obesity-induced hypertension in children. Methods:The levels of serum lipid, serum insulin (Ins) and cell membrane ATPase activities were measured in 104 middle school children aged 12~16 years. Results:The level of serum Ins was significantly higher,and the activities of Na -K -ATPase and Ca2 -ATPase were significantly lower in obese normotensive (ONT) and obese hypertensive (OHT) children than those in normal children. There were also significant differences in them between ONT and OHT children, the level of serum Ins was increased and the activities of the two ATPases were lowered in OHT children. Pearson correlation and multiple regression analysis shown that the level of Ins and the activity of Ca2 -ATPase were correlated with systolic pressure and the activity of Na -K -ATPase was correlated with diastolic pressure in OHT children. Conclusion: Hyperinsulinemia and decreased activities of Na -K -ATPse and Ca2 -ATPase may play important roles in pathogenesis of hypertension in obese children. |
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| Keywords: | obesity child hypertension insulin Na -K -ATPase Ca2 -ATPase |
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