Effect of acute and chronic benzodiazepines on plasma GABA in anxious patients and controls |
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Authors: | Peter P Roy-Byrne Deborah S Cowley Daniel Hommer David J Greenblatt Gerald L Kramer Frederick Petty |
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Institution: | (1) Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, 98195 Seattle, WA, USA;(2) Tufts University School of Medicine, Boston, MA, USA;(3) Veterans Affairs Medical Center, University of Texas Southwestern Medical School, Dallas, TX, USA;(4) Chief of Psychiatry, Harborview Medical Center, ZA-15, 325 9th Avenue, 98104 Seattle, WA, USA |
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Abstract: | The acute effects of diazepam on plasma GABA were determined in 18 patients with panic disorder, 13 patients with generalized anxiety disorder and 20 healthy controls. All subjects were benzodiazepine-naive. Four logarithmically increasing doses of diazepam/placebo were administered intravenously at 15-min intervals on 2 separate days. Plasma GABA was measured at baseline and 3 min after the highest dose of diazepam/placebo. There was an overall decrease in plasma GABA that was significantly greater following diazepam compared with placebo, but no group differences in response. In a separate group of 18 panic disorder patients receiving chronic benzodiazepine treatment with alprazolam, the same diazepam infusion procedure (no placebo day) produced decreases in plasma GABA similar to those seen in the untreated panic disorder patients. The clinical and physiologic implications of these findings are discussed. |
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Keywords: | Benzodiazepines Plasma GABA Anxiety |
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