老年高血压血管内皮细胞损伤与其功能的变化

目的:探讨老年人高血压病(EH)血管内皮细胞(VEC)损伤与内皮细胞功能的变化。方法:测定30例老年EH患者循环内皮细胞(CEC)、一氧化氮(NO)、内皮素(ET)水平与24例健康老年人进行比较。结果:EH组CEC、ET较对照组明显增加(P

CHANGES OF VASCULAR ENDOTHELAL CELL, NITRIC OXIDE AND ENDOTHELIN IN SENILE HYPERTENSION PATINETS

Objective: To study the relationship of changes of vascular endothelial cell (VEC), intric oxide (NO) and endothelin (ET) with hypertension. Method: To detect the levels of circular endothelial cell (CEC), NO and ET in plasma of 30 senile hypertension patients and 24 normal senile persons, and then to campare the results between the two groups. Result: The levels of plasmatic CEC and ET of hypertension group were significantly higher than control group's (P<0. 01), but plasmatic NO level was obviouly lower than control group's (P<0. 01). NO level had a significant negative correlation with ET level (r = 0. 43,P<0. 01), and ET level had a sigfincant positive correlation with CEC level (r = 0. 49, P < 0. 01 ). Conclusion: Vascular endothelial cell injury occurs in senile hypertension patients. The changes of NO and ET levels may be related to hypertensive pathogeny.