| 心跳停止时间对兔心肺复苏后脑损伤的影响 |
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| 引用本文： | 肖敏,张绪国,刘菊英,罗明,陈静宜,吕军. 心跳停止时间对兔心肺复苏后脑损伤的影响[J]. 郧阳医学院学报, 2010, 29(1): 37-39 |
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| 作者姓名： | 肖敏 张绪国 刘菊英 罗明 陈静宜 吕军 |
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| 作者单位： | 肖敏,张绪国,罗明,陈静宜(郧阳医学院附属太和医院急诊科,湖北 十堰,442000);刘菊英(郧阳医学院附属太和医院麻醉科,湖北 十堰,442000);吕军(郧阳医学院附属太和医院检验科,湖北 十堰,442000) |
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| 基金项目： | 湖北省教育厅资助项目 |
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| 摘 要： | 目的:探讨心跳停止时间对心肺复苏后神经元特异性烯醇化酶(NSE)的表达和脑损伤的影响。方法:40只兔气管夹闭窒息法制作心肺复苏模型,心跳骤停后4、5、6min进行复苏,分别在0、24、48、72、96、120h6个时间点测定血清NSE含量,并对兔脑损伤情况进行神经功能评分。结果:心肺复苏后24、48、72、96hNSE表达均明显高于假手术组,48h达峰值;心跳骤停组神经功能评分均明显高于假手术组,以复苏后24h最高;心跳骤停5、6min组间神经功能评分无差异(P>0.05);血清NSE水平与神经功能评分正相关(P<0.01)。结论:血清NSE水平评价CPR后脑损伤灵敏、客观。心跳停止4min复苏后脑组织损伤较轻;停止5min以上,脑组织损伤严重。
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| 关 键 词： | 心跳骤停 心肺复苏 脑损伤 神经元特异性烯醇化酶 |
Influence of Cardiac Arrest Time on Brain Injury after Cardiopulmonary Resuscitation in Rabbits |
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| XIAO Min,ZHANG Xu-guo,LIU Ju-ying,LUO Ming,CHEN Jing-yi,LV Jun. Influence of Cardiac Arrest Time on Brain Injury after Cardiopulmonary Resuscitation in Rabbits[J]. Journal of Yunyang Medical College, 2010, 29(1): 37-39 |
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| Authors: | XIAO Min ZHANG Xu-guo LIU Ju-ying LUO Ming CHEN Jing-yi LV Jun |
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| Affiliation: | XIAO Min1,ZHANG Xu-guo1,LIU Ju-ying2,LUO Ming,CHEN Jing-yi,LV Jun3 (1Department of Emergency,2Department of Anesthesiology,3Department of Clinical Laboratory,Taihe Hospital,Yunyang Medical College,Shiyan,Hubei 442000,China) |
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| Abstract: | Objective To explore the influence of cardiac arrest time on the expression of serum neuron-specific enolase (NSE) and brain injury.Methods The model of cardiopulmonary resuscitation(CPR) were prepared by the method of clipping trachea to asphyxia in 40 rabbits and resuscitation was taken at 4,5,6 minutes after cardiac arrest.The contents of serum NSE were determined at 0,24,48,72,96,120 h,respectively.The neurologic score was taken to evaluate the state of brain injury.Results The expression of NSE in resu... |
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| Keywords: | Cardiac arrest Cardiopulmonary resuscitation Brain injury Neuron-specific enolase |
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