创面修复中生长因子研究及临床干预新进展

创面修复是一个多因素参与的复杂而精细的生物学过程。创面局部生长因子及其受体活性下降和数量的相对和绝对缺乏是其难愈的重要病理生理基础。创面修复过程中生长因子不仅可以促进角质细胞增殖分化使创面再上皮化,还可改变细胞外基质,促进蛋白质、DNA和RNA的合成以及糖酵解,促进新生肉芽组织形成。因此,局部外用生长因子可以显著促进创面修复。在临床实践中,生长因子的应用方式也不断改善,同时与其相关的治疗方案也不断涌现,应用前景广泛。

Research and related therapies of growth factors in wound healing

Wound healing is a complex,multi-factor involved and delicate biological process.Its patho-physiological basis includes down-regulated activity and relative or absolute absence of growth factors and their re-ceptors in wounds.Growth factors have shown their implications on keratinocytes promoting its differentiation and proliferation to accelerate re-epithelialization.Growth factors also could influence the extracellular matrix,the syn-thesis of protein,DNA and RNA and glycolysis in wound healing to promote the formation of new granulation tissue. So there is a significant effect after the topical application of exogenous growth factors in wounds.In clinical prac-tice,the way of application will be continuously improved.At the same time,some other related methods will ap-pear.