青年人与老年人肺癌的比较

目的 对青年人肺癌（年龄≤40岁）和老年人肺癌（年龄≥70岁）的病理类型、临床表现、性别比例、临床分期及对治疗的选择进行比较。方法 回顾性收集6年来在我院经病理学证实青年人组70例及老年人组135例肺癌患者的年龄、性别、组织学分类、起始症状、临床分期及治疗经过进行比较。结果 （1）青年人组中女性患者比例较老年人组明显增高（P＜0.01)。青年人组腺癌的比例亦较老年组高。（2）青年组中出现胸痛症状的比例明显高于老年人组（P＜0.01)。（3）青年人组中中晚、期比例略高于老年人组，但统计学上无显著性差异。（4）青年人组中手术治疗及放化疗的比例要明显高于老年人组（P＜0.01)，老年人组中更倾向于保守治疗。结论 青年人肺癌与老年人肺癌相比，女性患者比例明显增高，腺癌比例增高，疾病进展迅速，恶性度高，且易误诊。早期诊断，积极治疗能提高肺癌的生存期。

Comparison between young and old patients with lung cancer

Objective The aim of this study was to compare the clinical characteristics, histological types, stage at diagnosis and treatment of young( < or = 40 years) and older ( >r =70 years) patients with lung cancer. Methods The study was designed as retrospective review of all lung cancer patients referred to the Sir Run Run Shaw Hospital over a 6-year period from 1995 to 2001. Data of demographics, presentation symptoms, histology, tumor staging, and treatment modality was obtained from all patients. Results It was found that significantly more female patients and adenocarcinoma in the younger group compared with the older patients. Cough was the most common presenting symptom in both the younger and older groups, followed by dyspnea, hemoptysis in the older group or chest pain in the younger group. There was no difference on the ratio of middle and advansed stage at diagnosis between the younger and older groups. The young patients tended to receive aggressive treatment more readily than the older patients did, and the older patients frequently received supportive care only. Conclusion The ratio of female and adenocarinoma was higher the disease was more malignant.developed faster and wrong diagnosis was often yanger group than that in older one. Patients could get better survival by early diagnosis and active treatment.