Migration and differentiation of hematopoietic stem cells in autoimmune mice of different ages

Migration and differentiation of hematopoietic stem cells were studied in autoimmune (NZB×NZW)F₁ mice of different ages. Migration of stem cells was shown to be reduced in old (NZB×NZW)F₁ mice. Irrespective of age, inhibition of differentiation of stem cells along the granuloid path of development was observed in (NZB×NZW)F₁ mice. It is suggested that in (NZB×NZW)F₁ mice there is either a defect of development of the T-lymphocyte subpopulation influencing differentiation of stem cells along the granuloid pathway or a genetic defect at the level of precursors of the granulocyte series (CFU_C).Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 89, No. 2, pp. 224–226, February, 1980.