The role of 15-deoxy-delta(12,14)-prostaglandin J(2), an endogenous ligand of peroxisome proliferator-activated receptor gamma, in tumor angiogenesis |
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| Authors: | Kim Eun-Hee Surh Young-Joon |
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| Affiliation: | a National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul 151-742, South Korea
b Cancer Research Institute, Seoul National University, Seoul 110-799, South Korea |
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| Abstract: | |
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| Keywords: | AP-1, activator protein-1 CO, carbon monoxide COX, cyclooxygenase 15d-PGJ2, 15-deoxy-Δ12,14-prostaglandin J2 ERK, extracellular signal-regulated kinase HIF, hypoxia inducible factor HO-1, heme oxygenase-1 HRE, hypoxia response element iNOS, inducible nitric oxide synthase MAPK, mitogen-activated protein kinase MMP, matrix metalloproteinase NF-κB, nuclear factor-κB NO, nitric oxide PPARγ, peroxisome prolifeator-activated receptor γ PPRE, PPAR response elements ROS/RNS, reactive oxygen/nitrogen species RXR, receptor for 9 cis-retinoid TGZ, troglitazone TZD, thiazolidinedione VEGF, vascular endothelial growth factor ZnPP, zinc protoporphyrin SnPP, tin protoporphyrin |
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