中药单体成分对慢性乙型肝炎免疫调节机制的研究策略及进展

对慢性乙型肝炎具有免疫调节作用的中药单体研究近况进行综述。应用计算机检索CNKI和PubMed数据库中2000-01/2012-9关于中药单体对慢性乙型肝炎免疫调节作用研究的文章,以"慢性乙型肝炎;中药单体;免疫调节机制"为检索词检索到126篇文章,进行归纳综述。应用体内体外实验已筛选出如白背叶根、黄芪甲苷、高三尖杉酯碱等多种中药单体成分,其作用机制与抑制乙型肝炎病毒(HBV)DNA复制、调节T细胞亚群、促进树突状细胞(DC)成熟、调节Toll-like受体表达、调节肝细胞凋亡信号等密切相关。中药单体在慢性乙型肝炎免疫调节中发挥着重要作用。但目前研究还存在如:药源和制剂质控问题、缺乏大规模循证医学研究、以及缺乏较长期疗效研究等问题,解决这些问题仍任重而道远。

Strategy and Progress on Monomer Components of Chinese Materia Medica for Immunoregulation of Chronic Hepatitis B

Objective: To review the research on monomer components of Chinese materia medica for immunoregulation of chronic hepatitis B. Method: The articles related to monomer components of Chinese materia medica for immunoregulation of chronic hepatitis B in CNKI database and PubMed Database from January 2000 to September 2012 were retrieved with the key words of'Chronic hepatitis B, monomer components of Chinese materia medica, mmunoregulation'. A total of 126 literatures were obtained from computer screen, and 45 documents of them were involved for summarization. Result: A lot of monomer components of Chinese materia medica has been screened, for example, root of whitebackleaf mallotus, astragaloside IV, homobarringtonie. The mechanisms is closely related with inhibiting HBVDNA replication, regulating the balance of Thl/Th2 cell factors, promoting the maturation of dendritic cell, regulating the express of Toll-like receptor, regulating the singal of hepatocyte apoptosis. Conclusion: The monomer components of Chinese materia medica play an key role in immunoregulation of chronic hepatitis B.But there are some problem need to be solved, for example, the control of herb resource and preparation, the lack of study on evidence based medicine in large sample and long term effect research. It is heavy responsibility to deal with these problems.