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| FSH受体基因多态性在中国IVF人群中分布及与卵巢反应性关系的研究 | |
| 引用本文： | 李路,夏丽娜,杜晶,张兆奉,孙晓溪. FSH受体基因多态性在中国IVF人群中分布及与卵巢反应性关系的研究[J]. 生殖与避孕, 2011, 31(9): 587-595 |
| 作者姓名： | 李路 夏丽娜 杜晶 张兆奉 孙晓溪 |
| 作者单位： | 1. 上海交通大学医学院附属国际和平妇幼保健院生殖中心,上海,200030;复旦大学附属妇产科医院上海集爱遗传与不育诊疗中心,上海,200011 2. 上海松江妇幼保健院,上海,201600 3. 上海市计划生育科学研究所,上海,200032 4. 复旦大学附属妇产科医院上海集爱遗传与不育诊疗中心,上海,200011 |
| 基金项目： | 本项目由上海市卫生局科研项目资助 |
| 摘 要： | 目的:探讨IVF-ET/ICSI患者中FSH受体(FSHR)基因多态性对控制促排卵中卵巢反应性及妊娠结局的影响。方法:分析行IVF-ET/ICSI的223例患者资料,其中长方案174例,短方案37例,微刺激方案12例。通过PCR扩增、纯化、基因测序分别测得223例患者FSHR体基因在外显子10上第680位及307位的基因型,根据不同基因型分为Asn680/Asn680、Ser680/Ser680、Asn680/Ser680;Thr307/Thr307、Ala307/Ala307、Ala307/Thr307各3组。比较223例患者不孕因素在各组的分布;比较174例长方案促排卵患者不同FSHR基因型亚组的卵巢反应及妊娠结局。结果:223例患者中,FSHR基因680位点上Asn/Asn组占52.0%,Ser/Ser组占12.1%,Asn/Ser组占35.9%,307位点上Ala/Ala组占12.1%,Thr/Thr组占48.4%,Ala/Thr组占39.5%。174例长方案患者中Ser680/Ser680组及Ala307/Ala307亚组的基础FSH值显著高于其它2个基因型组(P<0.05);FSH受体基因680、307位点多态性的改变在OHSS发生上无预测作用(P>0.05),但OHSS发生组中SS680的分布频率(4.6%)明显低于非OHSS组(15.1%)。FSHR基因680、307位点多态性的改变与临床妊娠率无相关性。结论:FSHR基因680、307位多态性的分布存在差异,FSHR基因多态性Ser680和AA307可能与卵巢反应性有关,FSHR基因680、307位多态性与临床妊娠率无关。 |
| 关 键 词： | 体外受精-胚胎移植(IVF-ET) 卵泡刺激素受体(FSHR) 单核苷酸多态性 控制性超促排卵(COH) 卵巢过度刺激综合征(OHSS) |
Effects of Follicle-Stimulating Hormone Receptor Gene Polymorphsim on Ovarian Response during Controlled Ovarian Hyperstimulaton |
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| Lu LI,Li-na XIA,Jing DU,Zao-feng ZHA,Xiao-xi SUN. Effects of Follicle-Stimulating Hormone Receptor Gene Polymorphsim on Ovarian Response during Controlled Ovarian Hyperstimulaton[J]. Reproduction and Contraception, 2011, 31(9): 587-595 | |
| Authors: | Lu LI Li-na XIA Jing DU Zao-feng ZHA Xiao-xi SUN |
| Affiliation: | Lu LI1,4,Li-na XIA2,Jing DU3,Zao-feng ZHAO3,Xiao-xi SUN4(1.Reproductive Medicine Center of the International Peace Maternity and Child Health Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai,200030)(2.Shanghai Songjiang Maternity and Child Health Hospital,201600)(3.Shanghai Institute of Planned Parenthood Research,200032)(4.Shanghai Jiai Genetic & IVF Center,Obstetrics and Gynecology Hospital,Shanghai Medical College,Fudan University,200011) |
| Abstract: | Objective: To investigate the effects of different gene polymorphisms of FSH receptor on ovarianresponse during controlled ovarian hyperstimulation(COH) in IVF-ET/ICSI patients.Methods: A total of 223women who underwent an IVF-ET/ICSI cycle were analyzed,including 174 in the long-term protocols,37 inshort-term protocols and 12 in mini-stimulation protocols.Following extraction,purification amphificationand sequercing of genomic DNA from the patients,the FSHR gene polymorphisms at position 680 and 307 weredi... |
| Keywords: | IVF-ET FSH receptor(FSHR) gene polymorphism controlled ovarian hyperstimulation(COH) ovarian hyperstimulation syndrome(OHSS) |
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