早孕妇女血清及蜕膜组织液对自然杀伤细胞活性及淋巴细胞增殖的影响

目的　探讨早孕妇女血清及蜕膜组织液对自然杀伤 (NK)细胞及淋巴细胞功能的影响。方法　采用同位素掺入法 ,检测 3 2例正常早孕妇女血清 (早孕血清组 )及蜕膜组织液 (蜕膜组织液组 )对正常妇女外周血中NK细胞活性 (% )及淋巴细胞增殖功能的影响 ,并采用 2 5例正常未孕妇女的血清作对照 (对照组 )。结果　早孕血清组、蜕膜组织液组及对照组的NK细胞活性分别为 (3 5 .8±3 .0 ) %、(19.1± 2 .9) %及 (46.1± 3 .2 ) % ,淋巴细胞增殖功能 每分钟同位素放射次数 (CPM) ]分别为(3 689± 4 5 6)CPM、(2 0 5 9± 2 88)CPM及 (4883± 64 3 )CPM ,3者间差异均有极显著性 (P <0 .0 1) ,且蜕膜组织液组均显著低于早孕血清组 (P <0 .0 0 5 )。结论　正常早孕妇女血清及蜕膜组织液具有免疫抑制作用 ,而蜕膜组织液可能是调节早期妊娠子宫局部免疫功能的重要因素之一。

Effects of serum and decidual tissue fluid in early pregnant women on natural killer cells activity and lymphocyte proliferation

Objective To study the effects of serum and decidual tissue fluid in early pregnant women on natural killer cells (NK cells) activity and lymphocyte proliferation. Method The effects of the serum and decidual tissue fluid obtained from 32 normal early pregnant women on NK cells activity and lymphocyte proliferation were tested by isotope incorporation methods. Sera of 25 nonpregnant women were chosen as controls. Results The NK cells activity and lymphocyte proliferation of sera and decidual tissue fluids from early pregnant women were lower than those of sera from nonpregnant women ( P <0.01). So were those of decidual tissue fluid as compared with sera during early pregnancy ( P <0.005). Conclusions Serum and decidual tissue fluid from early pregnant women expressed immunosuppressive effects.It is possible that these effects of decidual tissue fluid play an important role in regulating local immune status of pregnant uterus.