原发性干燥综合征肾损害

目的：探讨原发性干燥综合征（PSS）肾损害的临床与病理特征，提高对病的认识。方法：对38例PSS肾损害患进行肾活检并临床、实验室检查进行分析。结果：30／38为I型肾小管酸中毒（I型RTA），9／30合并低钾性麻痹，8／30合并骨质疏松或病理性骨折，4／30并泌尿系结石。肾病综合征及肾小球肾炎（GN）分别为4及3例。免疫病理22／38阳性，肾小球基底膜及系膜区主见IgC、IgA、IgM及C3沉积；病理示慢性间质性肾炎23例，肾小球肾炎23例。结论：PSS肾损害时，肾小球肾炎并非少见，应重视。

Clinical and Pathological Analysis of Primary Sjogren's Syndrome Renal Injury

Objective:In this study the clinical and pathological features of renal injury of primary Sjogren's syndrome (PSS) were discussed.Methods:Clinical,laboratory inspection and renal biopsy were made in 38 primary Sjogren's syndrome renal injury patients.Results:The spectrum of renal disorders in the 38 patients was as follows:type I renal tubular acidosis (type I RTA,30/38),intercurrent low potassium benumb(9/30),intercurrent osteoporosis or pathological fracture(8/30),intercurrent urinary calculus(4/30).Nephritic syndrome (3) and glomerulonephritis (GN,4) were also found in these patients.22/38 was immunologically pathologic positive.IgG?IgA?IgM and C 3 sedimentation were found on renal tubular basement membrane and membrane areas.Pathological analysis showed 23 patients with chronic interstitial nephritis,23 with glomerulonephritis. Conclusion:Primary Sjogren's syndrome renal injury may be associated with glomerulonephritis.