肺小细胞癌八例临床病理观察

目的探讨肺小细胞癌的临床病理特征、免疫组化、诊断及鉴别诊断。方法对8例肺小细胞癌进行组织形态学、免疫组化观察和文献复习。结果组织学显示瘤细胞形态较为一致，片状、巢状、带状或梁索状排列，浸润性生长，部分区域呈鳞状细胞癌或腺癌分化。免疫组化：CK、CEA阳性，部分瘤细胞Syn、CgA阳性；LCA、S-100阴性.结论肺小细胞癌是一种高度恶性肿瘤，具有特征性的组织学改变，应与非小细胞癌、大细胞神经内分泌癌、类癌、淋巴瘤、原始神经外胚层瘤、Merkd肿瘤等鉴别。

Small cell carcinoma of the lung: a clinicopathologic analysis

Objective To its diagnosis and explore the histopathologic and immunohistoehemical characteristics of small cell carcinoma of the lung and its diagnosis and differential diagnosis. Methods We observed the histopathologic and immunohistochemical results in 8 cases of small cell carcinoma and the related literature was reviewed. Rusults Histologically, the majority of the tumor was composed of cords or nest or sheets or loose aggregates of small cell; it had minor component of squamous and glandular differentiation. Immunohistoehemically, the tumor cells were positive CK,CEA, the partly small cells were positive for Syn,CgA. Conclusions Small cell carcinoma of the lung is a malignant tumor. It has a characteristic histopathologic pattern. Differential diagnosis of it includes lymphoma, primitive neuroectodermal tumour, Merkel cell carcinoma, non-small carcinoma, large cell neuroendocrine, careinoid.