| 胸腺五肽缓释微球的制备及其质量评价 |
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| 引用本文： | 李洪. 胸腺五肽缓释微球的制备及其质量评价[J]. 中国现代应用药学, 2009, 26(7): 582-584 |
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| 作者姓名： | 李洪 |
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| 作者单位： | 广州健心药业有限公司，广州 510663 |
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| 摘 要： | 目的确立胸腺五肽（TP-5）微球的制备及质量评价方法。方法以聚乳酸一羟基乙酸（PLGA）为载体材料，采用复乳法（w／o／w）制备TP-5长效缓释注射微球，考察其粒径大小、外观、包封率等理化性质；采用HPLC测定微球中TP-5的含量。结果TP-5微球球形圆整，包封率在80％以上，平均粒径为67．8μm，27d体外累积释放百分率在80％以上．结论TP-5微球的制备工艺合理，评价方法简便、快速、准确。
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| 关 键 词： | 胸腺五肽 缓释微球 质量评价 |
| 收稿时间： | 1900-01-01 |
Preparation and Quality Evaluation of the Thymopentin Sustained Release Microspheres |
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| LI Hong. Preparation and Quality Evaluation of the Thymopentin Sustained Release Microspheres[J]. The Chinese Journal of Modern Applied Pharmacy, 2009, 26(7): 582-584 |
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| Authors: | LI Hong |
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| Affiliation: | Guangzhou Jianxin Pharmaceutical Group Co.,Ltd, Guangzhou 510663, China |
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| Abstract: | OBJECTIVE To preparation testosterone undecanoate self-microemulsifying drug delivery systems (TU SMEDDS). METHOD The formulation of TU SMEDDS was obtained by pseudo-ternary phase diagram and the determination of self-microemulsifying efficiency. RP-HPLC |
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| Keywords: | testosterone undecanoate self-microemulsifying drug delivery systems formulation |
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