The relationship between the cervical and anal HPV infection in women with cervical intraepithelial neoplasia |
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| Affiliation: | 1. Hospital Na Bulovce and 1st School of Medicine, Charles University, Department of Gynaecology and Obstetrics, Budinova 2, Prague 8, 180 81, Czech Republic;2. Institute of Biostatistics and Analyses, Masaryk University, Kamenice 3, Brno, 625 00, Czech Republic;3. General University Hospital and 1st School of Medicine, Gynaecologic Oncology Centre, Charles University, Apolinarska 18, Prague 2, 128 51, Czech Republic;4. General University Hospital and 1st School of Medicine, Institute of Medical Biochemistry and Laboratory Diagnostics, Charles University, U Nemocnice 2, Prague 2, 128 08, Czech Republic;1. Hull and East Yorkshire Hospitals NHS Trust, Castle Hill Hospital, Castle Road, Cottingham HU16 5JQ, United Kingdom;2. The Yorkshire Laser Centre, Goole and District Hospital, Woodlands Avenue, East Yorkshire, Goole DN14 6RX, United Kingdom;1. Unit of infections and cancer, Cancer epidemiology research program, Catalan institute of oncology, IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain;2. CIBER en epidemiología y salud pública (CIBERESP), Barcelona, Spain;1. The University of Melbourne, Grattan Street, Parkville, Melbourne 3010, VIC, Australia;2. Regional HPV Reference Laboratory, Department of Microbiology and Infectious Diseases, The Royal Women''s Hospital, Parkville, VIC, Australia;3. Murdoch Childrens Research Institute, Parkville, VIC, Australia;4. Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, Australia;5. Department of Anatomical Pathology, Royal Women''s Hospital, 5th Floor, 20 Flemington Road, Parkville, Melbourne 3052, VIC, Australia;6. VCS Incorporated, 265 Faraday St, Carlton, Melbourne 3053, VIC, Australia;7. School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia;1. Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-Sen University, Guangdong, China;2. Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangdong, China |
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| Abstract: | BackgroundMore than 90% of cases of anal cancers are caused by high-risk human papillomavirus (HR HPV) infection and a history of cervical intraepithelial neoplasia (CIN) is established as possible risk factor.ObjectivesTo demonstrate relationship between anal and cervical HPV infection in women with different grades of CIN and microinvasive cervical cancer.Study designA total of 272 women were enrolled in the study. The study group included 172 women who underwent conization for high-grade CIN or microinvasive cervical cancer. The control group consisted of 100 women with non-neoplastic gynecologic diseases or biopsy-confirmed CIN 1. All participants completed a questionnaire detailing their medical history and sexual risk factors and were subjected to anal and cervical HPV genotyping using Cobas and Lynear array HPV test.ResultsCervical, anal, and concurrent cervical and anal HPV infections were detected in 82.6%, 48.3% and 42.4% of women in the study group, and in 28.0%, 26.0% and 8.0% of women in the control group, respectively. The prevalence of the HR HPV genotypes was higher in the study group and significantly increased with the severity of cervical lesion. Concurrent infections of the cervix and anus occurred 5.3-fold more often in the study group than in the control group. Any contact with the anus was the only significant risk factor for development of concurrent HPV infection.ConclusionsConcurrent anal and cervical HR HPV infection was found in nearly half of women with CIN 2+. The dominant genotype found in both anatomical locations was HPV 16. Any frequency and any type of contact with the anus were shown as the most important risk factor for concurrent HPV infection. |
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| Keywords: | HPV CIN Cervical infection Anal infection Anal cancer |
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