Electroencephalographic correlates of working memory deficits in children with Fetal Alcohol Spectrum Disorder using a single-electrode pair recording device |
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| Institution: | 1. Institute of Medical Sciences, Tzu-Chi University, Hualien, Taiwan;2. Department of Otolaryngology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan;3. Department of Pathology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan;4. Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan, Taiwan;5. Center for Nanotechnology, Chung Yuan Christian University, Taoyuan, Taiwan;6. Research Center of Excellence for Environment Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;7. Department of Dermatology, Kaohsiung Medical University, Kaohsiung, Taiwan;8. Department of Life Sciences, Tzu-Chi University, Hualien, Taiwan;1. Holistic Electronics Research Lab, Department of Electrical and Computer Engineering, University of Cyprus, Cyprus;2. KIOS Research Centre, University of Cyprus, Kallipoleos 75, 1678 Nicosia, Cyprus;1. School of Communication and Information Engineering, Shanghai University, China;2. Key Laboratory of Advanced Displays and System Application, Ministry of Education, China;1. Neurosciences Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA;2. Department of Psychology, University of California, San Diego, La Jolla, CA 92093, USA;3. Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, CA 92093, USA |
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| Abstract: | ObjectiveChildren with Fetal Alcohol Spectrum Disorder (FASD) exhibit cognitive deficits that can be probed using eye movement tasks. We employed a recently developed, single-sensor electroencephalographic (EEG) recording device in measuring EEG activity during the performance of an eye movement task probing working memory in this population.MethodsChildren with FASD (n = 18) and typically developing children (n = 19) performed a memory-guided saccade task requiring the participant to remember the spatial location of one, two or three stimuli. We hypothesized that children with FASD would (i) exhibit performance deficits, particularly at greater mnemonic loads; and (ii) display differences in theta (4–8 Hz) and alpha (8–12 Hz) frequency band power compared with controls.ResultsChildren with FASD failed to perform the task correctly more often than controls when presented with two or three stimuli, and demonstrated related reductions in alpha and theta power.ConclusionThese data suggest that the memory-guided task is sensitive to working memory deficits in children with FASD.SignificanceSimultaneous recording of EEG activity suggest differing patterns of underlying neural recruitment in the clinical group, consistent with previous literature indicating more cognitive resources are required by children with FASD in order to complete complex tasks correctly. |
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| Keywords: | Fetal Alcohol Spectrum Disorder Saccade Executive function Electroencephalogram Band power |
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