High frequency oscillations in intra-operative electrocorticography before and after epilepsy surgery |
| |
| Affiliation: | 1. Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Center Utrecht, The Netherlands;2. MIRA, Institute for Technical Medicine, University of Twente, The Netherlands;3. Montreal Neurological Institute, McGill University, Canada;4. Epilepsy Institutes in the Netherlands, SEIN, Heemstede, The Netherlands;1. Epilepsy Center, University Medical Center Freiburg, Mathildenstrasse 1, Breisacher Str. 64, 79106 Freiburg, Germany;2. Institute for Complex Systems and Mathematical Biology, University of Aberdeen, Meston Building, AB24 3UE Aberdeen, UK;3. Medical Physics, University Medical Center Freiburg, Breisacher Str. 60a, 79106 Freiburg, Germany;4. Department of Neuropediatrics and Muscular Disease, University Medical Center Freiburg, University of Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany;1. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA;2. Department of Biostatistics, Richard M. Fairbanks School of Public Health and School of Medicine, Indiana University, Indianapolis, USA;1. Klinik für Neurochirurgie, UniversitätsSpital und Universität Zürich, Switzerland;2. Neuropädiatrie, Universitäts-Kinderspital Zürich, Switzerland;3. Schweizerisches Epilepsie-Zentrum, Zürich, Switzerland;4. National Research University Higher School of Economics, Moscow, Russian Federation;5. Zentrum für Neurowissenschaften Zürich, ETH Zürich, Switzerland;1. Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;2. Division of Pediatric Neurosurgery, Department of Neurosurgery, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan;3. Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;4. Neuroscience Research Center, Taipei Medical University Hospital, Taipei, Taiwan;5. Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan;6. Division of Pediatric Neurology, Department of Pediatrics, Taipei Medical University Hospital, Taipei Medical University, Taiwan;7. Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;8. Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan;9. Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;10. Department of Pathology, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan;11. Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;1. Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan;2. Institute of Brain Science, Brain Research Center, National Yang-Ming University, Taipei, Taiwan;3. Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan;1. Neurosurgery Department, University Hospital Zurich, Zurich, Switzerland;2. Neuroscience Center, ETH and University of Zurich, Zurich, Switzerland;3. Montreal Neurological Institute and Hospital, Montreal, Quebec, Canada;4. MediCIS, INSERM, Faculté de Médecine, University of Rennes, Rennes, France |
| |
| Abstract: | ObjectiveRemoval of brain tissue showing high frequency oscillations (HFOs; ripples: 80–250 Hz and fast ripples: 250–500 Hz) in preresection electrocorticography (preECoG) in epilepsy patients seems a predictor of good surgical outcome. We analyzed occurrence and localization of HFOs in intra-operative preECoG and postresection electrocorticography (postECoG).MethodsHFOs were automatically detected in one-minute epochs of intra-operative ECoG sampled at 2048 Hz of fourteen patients. Ripple, fast ripple, spike, ripples on a spike (RoS) and not on a spike (RnoS) rates were analyzed in pre- and postECoG for resected and nonresected electrodes.ResultsRipple, spike and fast ripple rates decreased after resection. RnoS decreased less than RoS (74% vs. 83%; p = 0.01). Most fast ripples in preECoG were located in resected tissue. PostECoG fast ripples occurred in one patient with poor outcome. Patients with good outcome had relatively high postECoG RnoS rates, specifically in the sensorimotor cortex.ConclusionsOur observations show that fast ripples in intra-operative ECoG, compared to ripples, may be a better biomarker for epileptogenicity. Further studies have to determine the relation between resection of epileptogenic tissue and physiological ripples generated by the sensorimotor cortex.SignificanceFast ripples in intra-operative ECoG can help identify the epileptogenic zone, while ripples might also be physiological. |
| |
| Keywords: | Epilepsy surgery Focal epilepsy Electrocorticography High frequency oscillations |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
