Soft wearable contact lens sensor for continuous intraocular pressure monitoring |
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| Affiliation: | 1. Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA;2. David H. Koch Institute for Integrative Cancer Research, 77 Massachusetts Ave, Building 76-66, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;3. Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children''s Hospital, Harvard Medical School, Boston, MA 02115, USA;4. Small Molecule Mass Spectrometry, Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA;1. Inserm U1042, Hypoxia and Physiopathology Laboratory, University Grenoble Alpes, Grenoble, France;2. Department of Ophthalmology, University Hospital, CHU Grenoble, Grenoble, France;3. Hamilton Glaucoma Center, Shiley Eye Center and Department of Ophthalmology, University of California, San Diego, La Jolla, CA, USA;4. Glaucoma Center, Montchoisi Clinic, Swiss Vision Network, Lausanne, Switzerland;5. Department of Ophthalmology, University of Colorado School of Medicine, Denver, CO, USA;1. Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, New York;2. Department of Ophthalmology, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, New York;3. Sensimed AG, Lausanne, Switzerland |
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| Abstract: | Intraocular pressure (IOP) is a primary indicator of glaucoma, but measurements from a single visit to the clinic miss the peak IOP that may occur at night during sleep. A soft chipless contact lens sensor that allows the IOP to be monitored throughout the day and at night is developed in this study. A resonance circuit composed of a thin film capacitor coupled with a sensing coil that can sense corneal curvature deformation is designed, fabricated and embedded into a soft contact lens. The resonance frequency of the sensor is designed to vary with the lens curvature as it changes with the IOP. The frequency responses and the ability of the sensor to track IOP cycles were tested using a silicone rubber model eye. The results showed that the sensor has excellent linearity with a frequency response of ∼8 kHz/mmHg, and the sensor can accurately track fluctuating IOP. These results showed that the chipless contact lens sensor can potentially be used to monitor IOP to improve diagnosis accuracy and treatment of glaucoma. |
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| Keywords: | Glaucoma Intraocular pressure Contact lens sensor Resonance circuit |
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