Timely event-related synchronization fading and phase de-locking and their defects in migraine |
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| Affiliation: | 1. Department of Pediatrics, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, Republic of Korea;2. Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea;3. Department of Neurology and Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea;4. Department of Neurology, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, Republic of Korea;5. Seoul Brain Neurology Clinic, Seoul, Republic of Korea;6. Department of Neurology, Korea University Medical Center, Korea University College of Medicine, Seoul, Republic of Korea;1. Department of Rehabilitation, Charles University in Prague, Faculty of Medicine in Hradec Králové and University Hospital, Hradec Králové, Czech Republic;2. Department of Pathological Physiology, Charles University in Prague, Faculty of Medicine in Hradec Králové, Hradec Králové 500 38, Czech Republic;1. INSERM, U1028, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France;2. CNRS, UMR5292, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France;3. Université Lyon 1, Lyon F-69000, France;4. Hospices Civils de Lyon, Croix-Rousse Hospital, Neurology Department, Lyon F-69000, France;5. Tonkin Clinic, Villeurbanne F-69100, France;6. Hospices Civils de Lyon, Neurological Hospital, Functional Neurology and Epileptology Department, Lyon F-69000, France |
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| Abstract: | ObjectiveTo investigate the characteristics of event-related synchronization (ERS) fading and phase de-locking of alpha waves during passive auditory stimulation (PAS) in the migraine patients.MethodsThe subjects were 16 adult women with migraine and 16 normal controls. Electroencephalographic (EEG) data obtained during PAS with standard (SS) and deviant stimuli (DS) were used. Alpha ERS fading, the phase locking index (PLI) and de-locking index (DLI) were evaluated from the 10 Hz complex Morlet wavelet components at 100 ms (t100) and 300 ms (t300) after PAS.ResultsAt t100, significant ERS was found with SS and DS in the migraineurs and controls (P = 0.000). At t300 in the controls, ERS faded to zero for DS while in the migraineurs there was no fading for DS. In both groups the PLI for SS and DS was significantly reduced, i.e. de-locked, at t300 compared to t100 (P = 0.000). In the migraineurs, the DLI for DS was significantly lower than in the controls (P = 0.003).ConclusionThe alpha ERS fading and phase de-locking are defective in migraineurs during passive auditory cognitive processing.SignificanceThe defects in timely alpha ERS fading and in de-locking may play a role in the different attention processing in migraine patients. |
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| Keywords: | Migraine ERP Alpha oscillation ERS Phase locking index |
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