A systematic review of air pollution as a risk factor for cardiovascular disease in South Asia: Limited evidence from India and Pakistan |
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Institution: | 1. Institute of Public Health, University of Heidelberg, Heidelberg, Germany;2. Federal Postgraduate Medical Institute, Lahore, Pakistan;1. Institute of Health and Environment, Seoul National University, Seoul, Republic of Korea;2. Department of Occupational and Environmental Medicine, Ajou University School of Medicine, Suwon, Republic of Korea;1. Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing, PR China;2. Chongqing Institute of Science and Technology for Population and Family Planning, Chongqing, PR China;3. Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, PR China;4. Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, PR China;1. University of Torino, Department of Public Health and Pediatrics, Torino, Italy;2. University of Torino, Department of Chemistry, Torino, Italy;3. Unit of Respiratory Medicine, National Health Service (ASL TO2), Turin, Italy;1. School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong;2. Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong;1. Department of Infection Control and Infectious Diseases, RWTH Aachen University Hospital, Aachen, Germany;2. Department of Pediatrics, Division of Neonatology, RWTH Aachen University Hospital, Aachen, Germany;3. RWTH Aachen University Hospital, Aachen, Germany;4. Department of Pediatrics, RWTH Aachen University Hospital, Aachen, Germany;5. MVZ Labor Dr. Stein + Kollegen, Mönchengladbach, Germany;6. LDZ, University Hospital, Aachen, Germany;1. Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China;2. Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618104), Harbin 150081, China |
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Abstract: | Cardiovascular diseases (CVD) are major contributors to mortality and morbidity in South Asia. Chronic exposure to air pollution is an important risk factor for cardiovascular diseases, although the majority of studies to date have been conducted in developed countries. Both indoor and outdoor air pollution are growing problems in developing countries in South Asia yet the impact on rising rates of CVD in these regions has largely been ignored. We aimed to assess the evidence available regarding air pollution effects on CVD and CVD risk factors in lower income countries in South Asia. A literature search was conducted in PubMed and Web of Science. Our inclusion criteria included peer-reviewed, original, empirical articles published in English between the years 1990 and 2012, conducted in the World Bank South Asia region (Afghanistan, Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan and Sri Lanka). This resulted in 30 articles. Nine articles met our inclusion criteria and were assessed for this systematic review. Most of the studies were cross-sectional and examined measured particulate matter effects on CVD outcomes and indicators. We observed a bias as nearly all of the studies were from India. Hypertension and CVD deaths were positively associated with higher particulate matter levels. Biomarkers of oxidative stress such as increased levels of P-selection expressing platelets, depleted superoxide dismutase and reactive oxygen species generation as well as elevated levels of inflammatory-related C-reactive protein, interleukin-6 and interleukin-8 were also positively associated with biomass use or elevated particulate matter levels. An important outcome of this investigation was the evidence suggesting important air pollution effects regarding CVD risk in South Asia. However, too few studies have been conducted. There is as an urgent need for longer term investigations using robust measures of air pollution with different population groups that include a wider range of air pollutants and outcomes, including early indicators of CVD. These regions are facing burdens from increasing urbanization, air pollution and populations, generally weaker health infrastructure, aging populations and increased incidence of non-communicable diseases, included CVD. The extent to which the problem of air pollution and CVD will impact these countries will depend largely on the information available to inform policy and programs, which are still lacking, political will as well as social and economic development. |
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Keywords: | Cardiovascular disease Indoor air pollution Outdoor air pollution South Asia Inflammation Biomarkers Particulate matter |
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