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Age-related changes across the primary and secondary somatosensory areas: An analysis of neuromagnetic oscillatory activities
Institution:1. Department of Clinical Neurophysiology, Neurological Institute, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan;2. Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan;3. Department of Neurology, Neurological Institute, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan;1. Department of Clinical Neurophysiology and MEG Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands;2. Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands;3. Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands;4. Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, the Netherlands;1. Laboratoire d’Étude du Rayonnement et de la Matière en Astrophysique, Observatoire de Paris, UMR CNRS 8112, UPMC, 5 Place Jules Janssen, 92195 Meudon Cedex, France;2. Laboratoire d’Études Spatiales et d’Instrumentation en Astrophysique, Observatoire de Paris, UMR CNRS 8109, UPMC, UPD, 5 Place Jules Janssen, 92195 Meudon Cedex, France;1. Brain Research Center, National Yang-Ming University, Taipei, Taiwan;2. Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan;3. Department of Neurology, National Yang-Ming University, Taipei, Taiwan;4. Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan;1. Autonomous University of Queretaro (UAQ), Faculty of Engineering, Departments Biomedical and Electromechanical, Campus San Juan del Río, Río Moctezuma 249, Col. San Cayetano, C. P. 76807, San Juan del Río, Qro., Mexico;2. Department DICEAM of the Mediterranean University of Reggio Calabria, 89060, Reggio Calabria, Italy;3. Departments of Biomedical Informatics and Neuroscience, The Ohio State University, 470 Hitchcock Hall, 2070 Neil Avenue, Columbus, OH, 43220, USA;1. Institute of Neurology, Università Cattolica del Sacro Cuore, Rome, Italy;2. Fondazione Don Carlo Gnocchi ONLUS, Italy;3. Dipartimento di Scienze Neurologiche e Neurosensoriali, Unità di Neurologia e Neurofisiologia Clinica, Brain Investigation & Neuromodulation Lab, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte Viale Bracci, I-53100 Siena, Italy;4. IRCCS S. Raffaele-Pisana, Roma, Italy;5. Clinica S. Raffaele, Cassino, Italy;6. Department of Clinical Neurophysiology, University Hospital, Uppsala, Sweden;1. Dipartimento di Neuroscienze, Università di Parma, Parma, Italy;2. RTM (Rete Tecnologica Multidisciplinare), IIT (Istituto Italiano di Tecnologia) and Università di Parma, Italy;3. Dipartimento di Scienze Mediche e Chirurgiche, Università Magna Graecia, Catanzaro, Italy
Abstract:ObjectiveAge-related changes are well documented in the primary somatosensory cortex (SI). Based on previous somatosensory evoked potential studies, the amplitude of N20 typically increases with age probably due to cortical disinhibition. However, less is known about age-related change in the secondary somatosensory cortex (SII). The current study quantified age-related changes across SI and SII mainly based on oscillatory activity indices measured with magnetoencephalography.MethodsWe recorded somatosensory evoked magnetic fields (SEFs) to right median nerve stimulation in healthy young and old subjects and assessed major SEF components. Then, we evaluated the phase-locking factor (PLF) for local field synchrony on neural oscillations and the weighted phase-lag index (wPLI) for cortico-cortical synchrony between SI and SII.ResultsPLF was significantly increased in SI along with the increased amplitude of N20m in the old subjects. PLF was also increased in SII associated with a shortened peak latency of SEFs. wPLI analysis revealed the increased coherent activity between SI and SII.ConclusionsOur results suggest that the functional coupling between SI and SII is influenced by the cortical disinhibition due to normal aging.SignificanceWe provide the first electrophysiological evidence for age-related changes in oscillatory neural activities across the somatosensory areas.
Keywords:Secondary somatosensory area (SII)  Aging  Oscillatory activity  Phase-locking factor (PLF)  Weighted phase-lag index (wPLI)  Cortical disinhibition
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