Auditory event-related potentials at preschool age in children born very preterm |
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| Institution: | 1. Department of Clinical Sciences, Pediatrics, Lund University and Lund University Hospital, Lund, Sweden;2. Cognitive Brain Research Unit, Cognitive Science, Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland;3. Finnish Centre of Excellence in Interdisciplinary Music Research, University of Jyväskylä, Helsinki, Finland;4. Finnish Institute of Occupational Health, Helsinki, Finland;5. Department of Psychology, Lund University, Lund, Sweden;6. Department of Clinical Sciences, Neurophysiology, Lund University and Lund University Hospital, Lund, Sweden;7. Children’s Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland;1. Department of Pediatrics, Hanyang University College of Medicine, Seoul, South Korea;2. Department of Electronic Engineering, Hanyang University, Seoul, South Korea;3. Department of Psychiatry, Hanyang University, Seoul, South Korea;4. Department of Radiology, Hanyang University College of Medicine, Seoul, South Korea;5. Division of Neonatology and Developmental Medicine, Seoul Hanyang University Hospital, Seoul, South Korea;6. Department of Biomedical Engineering, Hanyang University, Seoul, South Korea;1. Cognitive Psychology Department, Faculty of Pedagogy and Psychology, Eötvös Loránd University, Izabella utca 46, H-1064 Budapest, Hungary;2. Research Group of Developmental Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Szondi utca 83-85, H-1068 Budapest, Hungary;3. Follow up Center for Developmental Neurology, I. Department of Obstetrics and Gynecology, Semmelweis University, Baross utca 27, H-1085 Budapest, Hungary;1. Center for Perinatal Research, Abigail Wexner Research Institute, Nationwide Children''s Hospital, Columbus, OH;2. Department of Pediatric Otorhinolaryngology, Nationwide Children''s Hospital, Columbus, OH;3. Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA;4. Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of Atlanta, Atlanta, GA;5. Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN;1. Department of Radiology, University Hospital Bonn, Sigmund Freud-Str. 25, 53105 Bonn, Germany;2. Department of Neonatology, University Hospital Bonn, Sigmund Freud-Str. 25, 53105 Bonn, Germany;3. Department of Neuroradiology, Klinikum Rechts der Isar, Technische Universität München, Ismaninger str. 22, 81664 Munich, Germany;4. Department of Psychiatry, Klinikum Rechts der Isar, Technische Universität München, Ismaninger str. 22, Munich 81664, Germany;5. TUM-Neuroimaging Center of Klinikum rechts der Isar, Technische Universität München, Ismaninger str. 22, Munich 81664, Germany;6. Graduate School of Systemic Neurosciences GSN, Ludwig Maximilians Universität, Biocenter, Department Biology II Neurobiology, Großhaderner Str. 2, D-82152 Planegg-Martinsried, Germany;7. Department of Developmental Psychology, Ruhr-University Bochum, Universitätsstraße 150, Bochum 44801, Germany;8. Department of Psychology, University of Warwick, University Road, Coventry CV4 7AL, UK;9. Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK |
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| Abstract: | ObjectiveTo assess auditory event-related potentials at preschool age in children born very preterm (VP, 27.4 ± 1.9 gestational weeks, n = 70) with a high risk of cognitive dysfunction.MethodsWe used an oddball paradigm consisting of a standard tone randomly replaced by one of three infrequent deviants (differing in frequency, sound direction or duration).ResultsThe P1 and N2 latencies were inversely correlated to age (50–63 months) both in VP (r = ?0.451, p < 0.001, and r = ?0.305, p = 0.01, respectively) and term born controls (TC; n = 15). VP children had smaller P1 than near-term (n = 12) or TC (1.70 ± 0.17 μV vs 2.68 ± 0.41 and 2.92 ± 0.43, respectively; p < 0.05). Mismatch negativity response did not differ between groups.ConclusionsOur data suggest a fast maturation of P1 and N2 responses with fast decrease in P1 and N2 latencies around the age of 5 years. Mismatch negativity response does not seem to be a robust measure for defining abnormalities in VP children.SignificanceIn ERP studies in preschool children, even small, non-significant group differences in age at recording should be corrected for. Very preterm born children at preschool age have aERP patterns as earlier described in full-term born children with cognitive deficits. |
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| Keywords: | Very premature infant Event-related potential (ERP) Mismatch negativity (MMN) N1 P2 Maturation Cognitive disorders |
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