Impulsive and compulsive behaviors among Danish patients with Parkinson's disease: Prevalence,depression, and personality |
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| Affiliation: | 1. Institute of Psychiatry and Psychology, Department of Neuroscience, Catholic University of the Sacred Heart, Rome, Italy;2. Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson''s Disease, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada;3. Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, UK;4. Department of Neuroscience and Imaging, “G. d''Annunzio” University of Chieti-Pescara, Italy;5. Institute of Neurology, Department of Neuroscience, Catholic University of the Sacred Heart, Rome, Italy;1. Department of Psychology, University of Campania Luigi Vanvitelli, Caserta, Italy;2. Institute of Diagnosis and Health, Hermitage-Capodimonte, Naples, Italy;3. Neurodegenerative Diseases Centre, Department of Medicine and Surgery, University of Salerno, Italy;4. Department of Motor Sciences and Health, University “Parthenope”, Naples, Italy |
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| Abstract: | IntroductionDopaminergic medication administered to ameliorate motor symptoms of Parkinson's disease is associated with impulse control disorders, such as pathological gambling, hypersexuality, compulsive buying, and binge eating. Studies indicate a prevalence of impulse control disorders in Parkinson's disease of 6–16%.ObjectiveTo estimate the prevalence of impulsive and compulsive behaviors among Danish patients with Parkinson's disease and to explore the relation of such behavioral disorders to depression and personality.Methods490 patients with Parkinson's disease (303 males), identified through the National Danish Patient Registry, were evaluated with: 1) the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease; 2) the Geriatric Depression Scale; and 3) the NEO-Personality Inventory.Results176 (35.9%) patients reported impulsive and compulsive behaviors sometime during Parkinson's disease (current symptoms in 73, 14.9%). Hereof, 114 (23.3%) reported multiple behavioral symptoms. Patients with behavioral symptoms were significantly younger, were younger at PD onset, had longer disease duration, displayed more motor symptoms, and received higher doses of dopaminergic medication than patients without behavioral symptoms. Furthermore, they reported significantly more depressive symptoms and scored significantly higher on neuroticism and lower on both agreeableness and conscientiousness than patients without behavioral symptoms.ConclusionA history of impulsive and compulsive behaviors are common in Danish patients with Parkinson's disease and have clinical correlates that may allow identification of patients at risk for developing these behaviors. |
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| Keywords: | Parkinson's disease Impulse control disorders Depression Personality |
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