Oral supplementation with troxerutin (trihydroxyethylrutin), modulates lipid peroxidation and antioxidant status in 1,2-dimethylhydrazine-induced rat colon carcinogenesis |
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| Institution: | 1. Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India;2. Department of Pathology, Rajah Muthiah Medical College, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India;3. Department of Surgery, Rajah Muthiah Medical College, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India;1. IFISE, CONICET-UNR, Rosario, S2002LRL, Argentina;2. IBR, CONICET-UNR, Rosario, S2002LRL, Argentina;3. Facultad de Ciencias Médicas, Universidad Nacional de Rosario (UNR), Rosario, S2002LRL, Argentina;4. Facultad de Ciencias Bioquímicas y Farmacéuticas, UNR, Rosario, S2002LRL, Argentina;1. Key Laboratory of Environmental Medicine and Engineering; Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China;2. Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing 210009, China;3. Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China;1. School of Public Health, Guiyang Medical University, Guiyang 550004, PR China;2. Guiyang Centers for Diseases Control and Prevention, Guiyang 550001, PR China;1. Center for Integrated Risk Research, Cellular and Molecular Toxicology Laboratory, Korea Institute of Science & Technology P.O. Box 131, Cheongryang, Seoul 130-650, Korea;2. School of Life Sciences and Biotechnology, Korea University, Anam-Dong, Seoungbuk-Gu, Seoul 136-791, Korea;3. Department of Marine Sciences, Incheon National University, 12-1 Songdo-dong, Yeonsu-gu, Incheon 406-772, Korea |
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| Abstract: | The present study was aimed to investigate the chemopreventive potential of troxerutin on 1,2-dimethylhydrazine (DMH) induced rat colon carcinogenesis by evaluating the antioxidant and lipid peroxidation (LPO) status. Rats were randomly divided into six groups. Group I rats served as control. Group II rats received troxerutin (50 mg/kg b.w., p.o.) for 16 weeks. Groups III–VI rats received subcutaneous injections of DMH (20 mg/kg b.w., s.c.) once a week, for the first 4 weeks. In addition to DMH, groups IV–VI rats received troxerutin at the doses of 12.5, 25 and 50 mg/kg b.w., respectively. In DMH treated rats, our results showed decreased activities of antioxidants and increased levels of LPO in the liver. Moreover, LPO and antioxidants in the colon were found to be significantly diminished in DMH the treated rats. Furthermore, enhanced activity of colonic vitamin C and vitamin E levels were observed in DMH alone treated rats (group III), which was significantly reversed on troxerutin supplementation. Troxerutin at the dose of 25 mg/kg b.w. had shown profound beneficial effects by exhibiting near normal biochemical profile and well-preserved colon histology as compared to the other two tested doses (12.5 and 50 mg/kg b.w.). These findings suggest that troxerutin could serve as a novel agent for colon cancer chemoprevention. |
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| Keywords: | Chemoprevention Troxerutin Colon cancer 1 2-Dimethylhydrazine Oxidative stress |
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