Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop |
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| Authors: | Ling-ling Shen Ming-liang Jiang Si-si Liu Min-chun Cai Zhong-qiu Hong Li-qing Lin Yan-yan Xing Gui-lin Chen Rui Pan Li-juan Yang Ying Xu Jun Dong |
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| Affiliation: | 1.Department of Pathophysiology, Key Laboratory of the State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou, Guangdong Province, China;2.GHM Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China;3.Department of Orthopedics, First Affiliated Hospital, Medical College of Jinan University, Guangzhou, Guangdong Province, China |
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| Abstract: | Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp120 V3 in rats, but the electrophysiological mechanism remains unknown. Using extracellular microelectrode recording techniques, this study confirmed that the gp120 V3 loop could suppress long-term potentiation in the rat hippocampal CA1 region and synaptic plasticity, and that curcumin could antagonize these inhibitory effects. Using a Fura-2/AM calcium ion probe, we found that curcumin resisted the effects of the gp120 V3 loop on hippocampal synaptosomes and decreased Ca2+ concentration in synaptosomes. This effect of curcumin was identical to nimodipine, suggesting that curcumin improved the inhibitory effects of gp120 on synaptic plasticity, ameliorated damage caused to the central nervous system, and might be a potential neuroprotective drug. |
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| Keywords: | nerve regeneration curcumin neurons HIV-1 gp120 V3 loop plasticity HIV-associated neurocognitive disorders output/input curve long-term potentiation excitatory postsynaptic potential paired-pulse facilitation Ca2+ synaptosome NSFC grants neural regeneration |
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