Lymphocyte activation in silica-exposed workers |
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| Institution: | 1. Department of Pharmacology and Hemocenter, Faculty of Medical Sciences, FCM, State University of Campinas—UNICAMP, Campinas, SP, Brazil;2. Department of Genetics, Neuroimmunology Unit, Evolution and Bioagents, Institute of Biology, State University of Campinas—UNICAMP, Campinas, SP, Brazil;3. Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands;4. Department of Preventive and Social Medicine, Occupational Medicine Area, Faculty of Medical Sciences, FCM, State University of Campinas—UNICAMP, Campinas, SP, Brazil;5. Maastricht University, Maastricht, The Netherlands;6. Sint Franciscus Gasthuis, Rotterdam, The Netherlands;1. Department of Environmental Studies, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8563, Japan;2. Department of Obstetrics and Gynecology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan;3. Shimadzu Techno-Research, Inc., #1 Nishinokyo-Shimoaicho, Nakagyo-ku, Kyoto 604-8436, Japan;4. Japan Public Health Association, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan;5. Department of Psychiatry and Neurology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan;1. Biomedical Sciences Graduate Program, Hermínio Ometto University Center – UNIARARAS, Av. Dr. Maximiliano Baruto 500, PC 13607-339 Araras, SP, Brazil;2. Department of Functional and Structural Biology, IB, State University of Campinas – UNICAMP, Av. Bertrand Russel, s/no Cx Postal 6109, PC 13083-865 Campinas, SP, Brazil;1. Environment and Health Research Unit, Research Institute for Health Sciences, Chiang Mai University, Thailand;2. Department of Environmental Health, Rollins School of Public Health, Emory University, USA;1. Department of Psychology, Umeå University, SE-901 87 Umeå, Sweden;2. Department of Public Health and Clinical Medicine, Umeå University, Sweden;1. Université Bordeaux, ISPED, Laboratoire Santé Travail Environnement, F-33000 Bordeaux, France;2. INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, F-33000 Bordeaux, France;3. CHU de Bordeaux, Service de Médecine du Travail, F-33000 Bordeaux, France;4. INSERM, UMR1086-Cancers et Préventions, F-14000 Caen, France;5. Univ. Caen Basse-Normandie, F-14000 Caen, France;6. Centre François Baclesse, F-14000 Caen, France;7. CHU de Bordeaux, Service de Pneumologie, F-33400 Pessac, France;1. Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia;2. Department of Environmental Health Science, College of Public Health, University of Georgia, Athens 30602, GA, USA;3. Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia |
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| Abstract: | Exposure to silica dust has been examined as a possible risk factor for autoimmune diseases, including systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus and ANCA-associated vasculitis. However, the underlying cellular and molecular mechanisms resulting in the increased prevalence of autoimmunity remain elusive. To clarify these mechanisms, we studied various markers of immune activation in individuals occupationally exposed to silica dust, i.e., serum levels of soluble IL-2 receptor (sIL-2R), levels of IL-2, other pro- and anti-inflammatory cytokines and lymphoproliferation. Our results demonstrate that silica-exposed individuals present important alterations in their immune response when compared to controls, as shown by increased serum sIL-2R levels, decreased production of IL-2 and increased levels of the pro-inflammatory (IFN-γ, IL-1α, TNF-α, IL-6) as well as anti-inflammatory (IL-10 and TGF-β) cytokines. Furthermore, silica-exposed individuals presented enhanced lymphoproliferative responses. Our findings provide evidence that the maintenance of immune homeostasis may be disturbed in silica-exposed individuals, possibly resulting in autoimmune disorders. |
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| Keywords: | Lymphocytes Soluble IL-2 receptor alpha Interleukin-2 Silica Cytokines Autoimmunity |
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