Taurine mitigates cognitive impairment induced by chronic co-exposure of male Wistar rats to chlorpyrifos and lead acetate |
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| Affiliation: | 1. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Abuja, Nigeria;2. Department of Physiology and Pharmacology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;3. Department of Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria;1. IFISE, CONICET-UNR, Rosario, S2002LRL, Argentina;2. IBR, CONICET-UNR, Rosario, S2002LRL, Argentina;3. Facultad de Ciencias Médicas, Universidad Nacional de Rosario (UNR), Rosario, S2002LRL, Argentina;4. Facultad de Ciencias Bioquímicas y Farmacéuticas, UNR, Rosario, S2002LRL, Argentina;1. Key Laboratory of Environmental Medicine and Engineering; Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China;2. Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing 210009, China;3. Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China;1. School of Public Health, Guiyang Medical University, Guiyang 550004, PR China;2. Guiyang Centers for Diseases Control and Prevention, Guiyang 550001, PR China;1. Center for Integrated Risk Research, Cellular and Molecular Toxicology Laboratory, Korea Institute of Science & Technology P.O. Box 131, Cheongryang, Seoul 130-650, Korea;2. School of Life Sciences and Biotechnology, Korea University, Anam-Dong, Seoungbuk-Gu, Seoul 136-791, Korea;3. Department of Marine Sciences, Incheon National University, 12-1 Songdo-dong, Yeonsu-gu, Incheon 406-772, Korea |
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| Abstract: | Organophosphate pesticides and heavy metals are ubiquitous environmental pollutants and neurotoxicants. We investigated the effects of taurine (an antioxidant; TA) on oxidative stress and cognition in male Wistar rats co-treated with chlorpyrifos (an organophosphate pesticide; CPF) and lead acetate (heavy metal; LA). The Wistar rats were divided into 5 groups of 10 rats each. The first two groups were administered with distilled water and soya oil respectively. The remaining three groups were administered with taurine (TA), 50 mg/kg body weight, CPF + LA group [CPF (4.25 mg/kg, 1/20 LD50] and LA (233.25 mg/kg, 1/20 LD50) and TA + CPF + LA group [TA (50 mg/kg), CPF (4.25 mg/kg) and LA (233.25 mg/kg)]. The xenobiotics were administered once daily by oral gavage for 16 weeks. The results showed reductions in the activities of brain antioxidant enzymes and acetylcholinesterase, increased lipoperoxidation and histopathological alterations of the cerebral cortex in the CPF + LA group. However, TA mitigated perturbations in the activities of the antioxidant enzymes and acetylcholinesterase, counteracted oxidative stress and brain lipoperoxidation and attenuated neuronal degeneration induced by joint CPF and LA-induced neurotoxicity. The results suggested that TA is neuroprotective following chronic co-exposure of rats to CPF and LA. |
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| Keywords: | Taurine Chlorpyrifos Lead acetate Cognition Oxidative stress Neuroprotection |
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