Dopamine-responsive pattern in tremor patients |
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Affiliation: | 1. Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland;2. Rehabilitation Engineering Laboratory, Department of Health Sciences and Technology, ETH Zurich, CH-8092, Switzerland;1. Parkinson Institute – Istituti Clinici di Perfezionamento, Milano, Italy;2. Biometry and Statistics Service, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;3. Nutrition and Dietetics Service, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy |
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Abstract: | BackgroundDiagnosis and treatment of tremor are largely based on clinical assessment. Whereas in some patients tremor may respond to dopaminergic treatment, in general l-Dopa response to tremor varies considerably. The aim of this study was to predict l-Dopa response by accelerometry.MethodsWe included 60 tremor patients and measured harmonic oscillations by accelerometry. In addition to neurological assessment, we performed l-Dopa challenge tests and the individual tremor response was compared to the amount of harmonic oscillations.ResultsWe found a strong correlation between harmonic oscillations and clinical l-Dopa response. Similarly, harmonic oscillations were significantly greater in patients with subjective tremor reduction upon l-Dopa administration.ConclusionsWe conclude that harmonic oscillations are a measure for l-Dopa response to tremor irrespective of the underlying disease. Because of the observational character of the study, any causal relation remains speculative. Nevertheless, we propose a novel, non-invasive approach to predict l-Dopa response in tremor patients. |
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Keywords: | Tremor Quantitative tremor analysis |
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