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Infective endocarditis and meningitis due to Scedosporium prolificans in a renal transplant recipient
Institution:1. Center for Infectious Diseases, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara, Japan;2. Second Department of Internal Medicine, Nara Medical University, Nara, Japan;3. Department of Urology, Nara Medical University, Nara, Japan;1. Laboratory of parasitology and mycology, UH Habib Bourguiba, Sfax, Tunisia;2. Ophthalmology service, UH Habib Bourguiba, Sfax, Tunisia;1. Servicio de Dermatología, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, España;2. Servicio de Anatomía Patológica, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, España;1. Division of Pulmonary Medicine, Allergy, and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka, Japan;2. Department of Pulmonary Medicine, Iwate Prefectural Kuji Hospital, Kuji, Japan;3. Division of Neurology and Gerontology, Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka, Japan;4. Department of Pulmonary Medicine, Iwate Prefectural Miyako Hospital, Miyako, Japan;5. Medical Mycology Research Center, Chiba University, Chiba, Japan;6. Department of Critical Care Medicine, Critical Care and Emergency Center, Iwate Medical University School of Medicine, Morioka, Japan;7. Department of Surgical Pathology, Toho University School of Medicine, Tokyo, Japan;1. Centro oftalmológico Virgilio Galvis, Floridablanca, Colombia;2. Fundación Oftalmológica de Santander, FOSCAL, Floridablanca, Colombia;3. Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia;4. Laboratorio Clínico Higuera Escalante-Centro de Diagnóstico ocular (OCULAB), Floridablanca, Colombia;5. Facultad de Ciencias de la Salud, Medicina, Universidad El Bosque, Bogotá, Colombia;1. Department of Cardiac, Thoracic, and Vascular Surgery, National University of Singapore, Singapore;2. Division of Microbiology, Department of Laboratory Medicine, National University of Singapore, Singapore;3. Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;1. Department of Medicine, University of Calgary, Calgary, Alberta, Canada;2. Department of Surgery, University of Alberta, Edmonton, Alberta, Canada;3. Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Abstract:Scedosporium prolificans is a ubiquitous filamentous fungi that may cause disseminated diseases in neutropenic patients with hematological malignancies. We report a fatal case of renal transplant recipient who developed both infective endocarditis and meningitis due to S. prolificans during treatment with micafungin and itraconazole for chronic necrotizing aspergillosis. Breakthrough Scedosporium infection should be considered among differential diagnosis of invasive fungal diseases in patients with renal transplant recipients receiving antifungal agents.
Keywords:Kidney transplantation  Disseminated infection  Infective endocarditis  Meningitis
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