Intensity-modulated whole pelvic radiotherapy provides effective dosimetric outcomes for cervical cancer treatment with lower toxicities |
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| Affiliation: | 1. Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA;2. Medical College of Georgia at Augusta University, Augusta, GA;3. Varian Medical Solutions, Varian Medical Systems, Oncology Systems, Atlanta, GA;4. Department of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL;1. Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, Calif;2. Division of Thoracic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, Calif;1. Department of Radiation Oncology, Gustave Roussy Cancer Campus, Villejuif, France;2. Department of Radiology and Medical Physics, Medical School, University of Cordoba, Spain;3. Institut Curie, Paris, France;4. PSL Research University, Paris, France;5. Inserm, U900, Paris, France;6. Mines Paris Tech, Fontainebleau, France;7. CNRS, UMR144, Paris, France;8. Department of Radiation Oncology, IUCT Oncopole, Toulouse, France;9. Service de Biostatistique et d’Epidemiologie, Gustave Roussy, Villejuif, France;10. INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif, France;11. Department of Medical Oncology, Institut Curie, Paris, France;12. Department of Radiation Oncology, Reina Sofia University Hospital, Cordoba, Spain |
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| Abstract: | PurposeTo compare the efficacy of intensity-modulated radiotherapy, three-dimensional conformal radiotherapy, and conventional radiotherapy for cervical cancer treatment.Materials and methodsWhole pelvis intensity-modulated radiotherapy, three-dimensional conformal radiotherapy, and conventional radiotherapy plans were designed for 16 patients with stage IIB cervical cancer, each using the prescribed dose of 50.4 Gy/28 fractions. Dose–volume histograms of the target volume and organs at risk were evaluated.ResultsCompared to the 3D conformal and conventional radiotherapy plans, the intensity-modulated radiotherapy plan demonstrated superior conformal treatment. The mean planning target volume dose of all three plans reached the target effective therapeutic dose. The planning target volume dose of the intensity-modulated radiotherapy plan was significantly higher than that of either the three-dimensional conformal radiotherapy or conventional radiotherapy plan (P < 0.05). When more than 30 Gy was administered in intensity-modulated radiotherapy, organs at risk including the small intestine, rectum, bladder, and bone marrow received a significantly reduced volume of radiation. In comparison of the average planning target volume doses, significant volume reductions in irradiation of organs at risk were obtained with full bladders.ConclusionsAn intensity-modulated radiotherapy plan with appropriate margins encompassing the primary tumour and potential microscopic pelvic disease reduces the dose to organs at risk without compromising target coverage. Intensity-modulated radiotherapy is an appropriate definitive treatment for patients with cervical cancer. |
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| Keywords: | Cervical cancer Intensity-modulated radiotherapy (IMRT) Bladder filling Cancer du col utérin Radiothérapie conformationnelle avec modulation d’intensité Remplissage vésical |
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