肝硬化患者血清脂质脂蛋白载脂蛋白检测对肝功能的评价

目的测定肝硬化患者血清总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、载脂蛋白A1和载脂蛋白B的水平,分析评估肝功能状态,并探讨临床意义。方法对肝硬化60例患者按照Child-Pugh评分标准进行评分,分A、B、C级3组,按临床分期分为失代偿期和代偿期,检测血清总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、载脂蛋白A1和载脂蛋白B以及总胆红素、白蛋白。另选健康体检者作对照组,比较其差异。结果肝硬化患者血清总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、载脂蛋白A1和载脂蛋白B水平均低于对照组(P<0.01);肝硬化失代偿期均低于代偿期、对照组(P<0.01或P<0.05),而代偿期尽管低于对照组,但差异无统计学意义(P>0.05);不同的分级间存在C级组

Evaluation of hepatic function by serum lipids, lipoprotein and apoprotein level in patients with liver cirrhosis

Objective To evaluate hepatic function by measuring the serum level of TC,TG,HDL,LDL,ApoA1 and ApoB in patients with liver cirrhosis.Methods Sixty patients diagnosed liver cirrhosis were divided into three groups of A,B and C by Child-Pugh′s grade,compensate and decompensate cirrhosis by clinic.Examine the level of TC,TG,HDL,LDL,ApoA1,ApoB,serum total bilirubin and albumin and compare these items with those in the control group.Results The level of TC,TG,HDL,LDL,ApoA1 and ApoB in patients was lower than the control(P<0.01);the level in decompensate cirrhosis was lower than the control and compensate(P<0.01 or P<0.05),but there was no significant difference between the compensate and the control(P<0.05). The significant difference existed in group A,B and C(P<0.01).It had a negative correlation to serum total bilirubin and a positive correlation to alumin.Conclusion The lipids disorder existed in liver cirrhosis;the serum level of lipids showing the status of the illness was able to evaluate the hepatic function and direct the clinical treatment.