Cytomegalovirus maculopapular eruption in a kidney transplant patient |
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Authors: | Herná n Trimarchi,Gabriel Casas,Rosana Jordan,Jorge Martí nez,Juan Schropp,Emilio Ar Freixas,Ernesto Efró n |
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Affiliation: | Department of Nephrology, Hospital Británico de Buenos Aires, Argentina;, Department of Pathology, Hospital Británico de Buenos Aires, Argentina;, Department of Infectious Diseases, Hospital Británico de Buenos Aires, Argentina |
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Abstract: | Abstract: Cytomegalovirus (CMV) is the most important viral agent in kidney transplantation. Clinical manifestations of CMV disease in transplantation include hepatitis, pneumonitis, pancreatitis, kidney allograft dysfunction, colitis, and meningoencephalitis. However, skin involvement is rare. We describe a severely compromised cadaveric‐kidney transplant recipient who developed renal failure, colonic ulcers, and a maculopapular rash accompanied by fever and malaise 4 months after transplantation. Only the skin biopsy was diagnostic and consistent with CMV disease. Intravenous ganciclovir administration resulted in clinical improvement of CMV‐induced skin lesions; kidney function normalized and the patient became asymptomatic after 14 days of ganciclovir therapy. Nephrologists should consider the diagnosis of CMV disease in the febrile immunosuppressed patient with skin involvement. Skin biopsy must be considered as a useful and safe procedure in patients with a rash to obtain a prompt diagnosis and efficiently treat this immunocompromised population. |
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Keywords: | cytomegalovirus kidney transplantation skin ganciclovir immunosuppression |
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