| 地灵丹对大鼠高尿酸血症肾病影响的实验研究 |
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| 引用本文： | 郑士荣,张景红,朱宇清,蔡淦. 地灵丹对大鼠高尿酸血症肾病影响的实验研究[J]. 上海中医药杂志, 2011, 0(10): 79-82 |
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| 作者姓名： | 郑士荣 张景红 朱宇清 蔡淦 |
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| 作者单位： | 中国人民解放军第85医院;上海市临床检验中心;上海中医药大学附属曙光医院; |
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| 基金项目： | 上海市医学发展基金(05Ⅱ010) |
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| 摘 要： | 目的观察地灵丹对大鼠高尿酸血症肾病的影响,并探讨相关作用机制。方法采用高嘌呤饲料制作高尿酸血症肾病大鼠模型,分为地灵丹治疗组、别嘌呤醇组、模型对照组及正常对照组,每组15只大鼠,分别给予相应的干预措施,持续4周。检测大鼠血尿酸、肌酐变化,观察肾脏组织学变化及细胞因子TGF-β1、TNF-α的表达。结果实验第14天,与正常对照组比较,各造模组血尿酸、血肌酐水平显著升高,差异有统计学意义（P〈0.05,P〈0.01）;与模型组比较,地灵丹组及别嘌呤醇组血尿酸、血肌酐水平均显著降低,差异有统计学意义（P〈0.01）。实验第28天,与正常对照组比较,模型组及地灵丹组血尿酸、血肌酐水平显著升高,差异有统计学意义（P〈0.01）,而别嘌呤醇组血尿酸水平出现显著降低,差异有统计学意义（P〈0.01）;与模型组比较,地灵丹组及别嘌呤醇组血尿酸、血肌酐水平显著降低,差异有统计学意义（P〈0.01）;与地灵丹组比较,别嘌呤醇组的血尿酸水平显著降低,血肌酐水平显著升高,差异有统计学意义（P〈0.01）;与正常对照组比较,其余各组TGF-β1、TNF-α阳性面积均显著增多,差异有统计学意义（P〈0.01）;与模型组比较,地灵丹组与别嘌呤醇组的TGF-β1阳性面积显著减少,差异有统计学意义（P〈0.05,P〈0.01）。与模型组比较,地灵丹组与别嘌呤醇组大鼠肾脏病理改变减轻。结论地灵丹可减缓高尿酸血症肾病大鼠肾脏损害的作用,其作用机制可能与调节TGF-β1、TNF-α等细胞因子有关。
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| 关 键 词： | 地灵丹 高尿酸血症肾病 尿酸 肌酐 |
Experimental study on preventive effects of Diling Pill on hyperuricemic nephropathy |
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| ZHENG Shi-rong,ZHANG Jing-hong,ZHU Yu-qing,CAI Gan .No. Hospital of Chinese People's Liberation Army,Shanghai. Experimental study on preventive effects of Diling Pill on hyperuricemic nephropathy[J]. Shanghai Journal of Traditional Chinese Medicine, 2011, 0(10): 79-82 |
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| Authors: | ZHENG Shi-rong ZHANG Jing-hong ZHU Yu-qing CAI Gan .No. Hospital of Chinese People's Liberation Army Shanghai |
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| Affiliation: | ZHENG Shi-rong1,ZHANG Jing-hong1,ZHU Yu-qing2,CAI Gan3 1.No.85 Hospital of Chinese People's Liberation Army,Shanghai,2.Shanghai Clinical Test Center,3.Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine |
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| Abstract: | Objective To observe the effects of Di Ling Pill(DLD) on hyperuricemic nephropathy in rats and evaluate its possible mechanisms.Methods We carried out this experiment in rats fed with high purine animal food.First,the rats were randomized into DLD group,allopurinol group,model group and normal group,15 rats in each group.Then,every group was intervened with corresponding drugs for 4 weeks.And then,we detected the change of serum creatinine(Scr),uricacid(UA) and renal pathology,and observed the expression of... |
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| Keywords: | Di Ling Pill hyperuricemic nephropathy creatinine uric acid |
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